GLENDALE, Ariz. (Interstat) — The Seattle Seahawks travel to face the Arizona Cardinals on Sunday, Sept. 20, 2026, at State Farm Stadium in an early-season National Football League matchup between teams that have started 1-0. Seattle opened its season with a 13-10 home win over New England on Wednesday, Sept. 9. Arizona opened with a 26-14 victory at the Los Angeles Chargers on Sept. 13. Both teams will try to remain unbeaten in the NFC.

Seattle’s offense received contributions from quarterbacks Drew Lock and Sam Darnold and running back Jadarian Price in the win over New England. The Seahawks will look for similar balance on the road against an Arizona defense that limited the Chargers in Week 1. Seattle’s next games after Sunday include a trip to Washington on Sept. 27, a home game against the Los Angeles Chargers on Oct. 4 and a home meeting with San Francisco on Oct. 11. The Seahawks also are scheduled to visit Denver on Oct. 15 before returning home to face Kansas City on Oct. 25. A Monday afternoon home game against Chicago is set for Nov. 2, followed by a home game against Arizona on Nov. 8.

Arizona’s offense is led by quarterback Jacoby Brissett, who completed 27 of 37 passes for 277 yards and one touchdown in the win over the Chargers. He also ran six times for 14 yards. Running back Tyler Allgeier carried 17 times for 61 yards and caught two passes for 9 yards. Jeremiyah Love added 11 carries for 41 yards, two receptions for 9 yards and one touchdown. The Cardinals will play at San Francisco on Sept. 27, at the New York Giants on Oct. 4 and at home against Detroit on Oct. 11. Arizona is scheduled to visit the Los Angeles Rams on Oct. 18 before hosting Denver on Oct. 25.

Seattle will visit Las Vegas on Nov. 15 and San Francisco on Nov. 29 before hosting Dallas on Dec. 7. Arizona will visit Dallas on Nov. 1, visit Seattle on Nov. 8, host the Los Angeles Rams on Nov. 15 and visit Kansas City on Nov. 22 before hosting Washington on Nov. 29. The game at State Farm Stadium is the first of two scheduled meetings between the teams this season, with the rematch set for Nov. 8 in Seattle.

Interstat’s game simulator projects a final score of Arizona 28, Seattle 24. Interstat’s ELO system gives Seattle a 93.4 percent probability to win. Arizona has been installed as a 3.5-point pregame favorite, and the over/under is 40.5.