PITTSBURGH (Interstat) — The surging Indianapolis Colts, owners of the NFL’s best record, will face a test of their legitimacy when they visit the Pittsburgh Steelers at Three Rivers Stadium on Sunday, Nov. 2, 2025.

The Colts (7-1) enter on a four-game winning streak, including a dominant 38-14 victory over Tennessee last week. Quarterback Daniel Jones has been efficient, completing 21 of 29 passes for 272 yards and three touchdowns in the win.

Conversely, the Steelers (4-3) are looking to rebound after a 35-25 home loss to Green Bay. Despite the defeat, veteran quarterback Aaron Rodgers threw for 219 yards and two touchdowns. Pittsburgh’s season has been marked by inconsistency, with narrow wins over the New York Jets and New England Patriots but losses in two of their last three games.

Despite the disparity in records, the Steelers have been installed as 3.5-point favorites by oddsmakers. A projection from Interstat simulates a 30-21 victory for Pittsburgh. The over/under is set at 50.5 points.

The game represents a classic clash between a high-flying offense and a traditionally tough defensive team at home. The Colts will look to continue their momentum, while the Steelers aim to leverage their home-field advantage to hand Indianapolis just its second loss of the season.