ORCHARD PARK, N.Y. (Interstat) — On Thursday, Sept. 17, 2026, Buffalo defeated Detroit 41-31 in a National Football League game at Highmark Stadium. Josh Allen threw for 248 yards and three touchdowns and ran for 69 yards and two scores for the Bills. Jared Goff passed for 327 yards and four touchdowns for the Lions. Amon-Ra St. Brown caught nine passes for 142 yards and two touchdowns. Allen opened the scoring with a 1-yard run, then hit Joshua Palmer for a 43-yard touchdown. Dawson Knox and Dalton Kincaid added scoring receptions. Goff connected with Jahmyr Gibbs, St. Brown twice and Sam LaPorta. James Cook III added a late 1-yard touchdown run. Greg Rousseau recorded two sacks, Bradley Chubb added 1.5 sacks and Christian Benford made eight tackles. Detroit’s Chuck Clark had 11 tackles, Derrick Barnes made seven tackles and a sack, and Aidan Hutchinson added a sack. Attendance was 60,644. Buffalo improved to 2-0; Detroit dropped to 1-1.