ORCHARD PARK, N.Y. (Interstat) — The Detroit Lions will visit the Buffalo Bills on Thursday, Sept. 17, 2026, at Highmark Stadium in Orchard Park, N.Y., for a National Football League game between teams that are each 1-0. Kickoff is scheduled under cloudy skies with a forecast temperature of 69 degrees. Both clubs opened with one-score victories.

Detroit enters after a 31-30 overtime win over New Orleans on Sunday, Sept. 13. Jared Goff completed 26 of 39 passes for 206 yards and two touchdowns and rushed twice for 2 yards. Jahmyr Gibbs had 29 carries for 156 yards, five receptions for 30 yards and two scores. Sione Vaki added two carries for 7 yards and one catch for 11 yards.

Buffalo opened its season with a 36-31 win at Houston on Sept. 13. Josh Allen completed 20 of 29 passes for 334 yards and two touchdowns, ran six times for 23 yards and scored two more touchdowns. James Cook III ran 13 times for 57 yards and caught three passes for 12 yards. Ray Davis had one carry for 3 yards and two kickoff returns for 51 yards.

Goff and Allen are the players to watch. Goff’s recent performance included 26 completions, 206 passing yards and two scoring throws. Allen’s day at Houston included 334 passing yards, 23 rushing yards and four total touchdowns.

After this game, Detroit’s listed upcoming schedule includes a trip to Buffalo on Sept. 18, a home game against the New York Jets on Sept. 27, visits to Carolina on Oct. 4 and Oct. 5, a trip to Arizona on Oct. 11, home games against Green Bay on Oct. 25, Minnesota on Nov. 1, New England on Nov. 15 and Tampa Bay on Nov. 22, and a visit to Miami on Nov. 8. Buffalo’s listed upcoming schedule includes Detroit at Buffalo on Sept. 18, the Los Angeles Chargers at home on Sept. 27, New England at home on Oct. 4, visits to the Los Angeles Rams on Oct. 12 and Oct. 13, a visit to Las Vegas on Oct. 18, Baltimore at home on Nov. 1, visits to Minnesota on Nov. 9 and Nov. 10, and a visit to the New York Jets on Nov. 15.

Interstat’s game simulator projects a final score of Buffalo 29, Detroit 21. Interstat’s ELO system gives Buffalo an 82.4 percent probability to win. Detroit has been installed as a pregame favorite with a spread of +4.5, and the over/under is 54.5.