INDIANAPOLIS (Interstat) — Lamar Jackson and Derrick Henry powered Baltimore to a 41-23 victory over Indianapolis on Sunday, Sept. 13, 2026, in a National Football League season opener at Lucas Oil Stadium. Jackson completed 17 of 25 passes for 324 yards and one touchdown and ran seven times for 40 yards and another score. Henry carried 24 times for 144 yards and scored three touchdowns, adding one reception for 19 yards. The Ravens improved to 1-0, while the Colts fell to 0-1 in front of an announced attendance of 65,045.

Baltimore’s offense struck through the air and on the ground, with Zay Flowers turning five catches into 150 yards and a touchdown. Mark Andrews added four receptions for 49 yards, Chris Moore had one catch for 53 yards and returned four kickoffs for 121 yards, and Justice Hill finished with six rushes for 18 yards and one reception for 10 yards. LaJohntay Wester had two catches for 15 yards, one kickoff return for 30 yards and three punt returns for 30 yards. Matthew Hibner caught one pass for 13 yards, Ja’Kobi Lane had one catch for 11 yards, and Durham Smythe added one reception for 4 yards. Rashod Bateman did not record a stat.

Indianapolis opened the scoring in the first quarter when Jonathan Taylor ran right end for a 1-yard touchdown. Spencer Shrader’s extra point missed wide right, leaving the Colts with a 6-0 lead. Baltimore answered at 8:20 of the first quarter when Jackson scored on a 5-yard left end run. Tyler Loop made the extra point. The Ravens took the lead at 4:05 when Henry ran right tackle for a 4-yard touchdown, and Loop’s extra point made it 14-6 after the opening period.

In the second quarter, Baltimore appeared to add another touchdown when Jackson found Lane for a 4-yard score, but the play was nullified by an offensive holding penalty on J. Gwyn. The 10-yard penalty was enforced at the Indianapolis 4, and the down was replayed. The Ravens did not wait long to score again. Jackson connected with Flowers for a 54-yard touchdown, and Loop added the extra point. Henry then broke free for a 32-yard touchdown on a left tackle run, pushing the Baltimore advantage to 28-6 after Loop’s kick.

Indianapolis responded before halftime. Taylor scored his second touchdown on a 3-yard right tackle run, and Shrader made the extra point to cut the deficit to 28-13. Baltimore closed the first half with a 57-yard field goal by Loop as time expired, sending the Ravens into the locker room with a 31-13 lead.

The Colts found points early in the third quarter when Shrader connected on a 58-yard field goal, trimming the margin to 31-16. Baltimore answered in the fourth quarter when Henry scored his third touchdown on a 3-yard left end run. Loop’s extra point made it 38-16. Indianapolis then put together a scoring drive capped by Daniel Jones’ 9-yard touchdown pass to Tyler Warren over the middle. Shrader’s extra point brought the Colts within 38-23.

Baltimore sealed the outcome with a 45-yard field goal by Loop with 4:09 remaining in the fourth quarter, completing the scoring at 41-23. Loop made both of his field-goal attempts and all of his extra-point tries. Shrader made a 58-yard field goal and one extra point but missed his first extra-point attempt wide right.

Jackson’s passing helped Baltimore control the game even as Indianapolis tried to stay within reach. He spread the ball to Flowers, Andrews, Moore, Wester, Hibner, Lane, Smythe and Hill. His 324-yard passing performance complemented Henry’s 144-yard rushing day, and Baltimore produced five touchdowns and two field goals.

For Indianapolis, Jones completed 19 of 31 passes for 166 yards and one touchdown. He also ran once for 4 yards. Taylor finished with 19 carries for 98 yards and two touchdowns and caught three passes for 23 yards. Alec Pierce had four receptions for 61 yards. Josh Downs recorded two catches for 37 yards and one tackle. Keenan Allen caught six passes for 32 yards. Warren had three receptions for 13 yards and one touchdown. Ashton Dulin returned one kickoff for 33 yards and made two tackles, while Seth McGowan had one reception for no yards and five kickoff returns for 164 yards.

Rigoberto Sanchez punted five times for 263 yards for the Colts. Baltimore’s Ryan Eckley punted three times for 140 yards. On defense, Baltimore’s Roquan Smith led the way with 11 tackles and one interception. Malaki Starks added seven tackles and one sack. Kyle Hamilton had five tackles. Marlon Humphrey and Travis Jones each finished with four tackles, and Trenton Simpson also had four tackles.

Indianapolis was led defensively by Akeem Davis-Gaither with eight tackles. Cam Bynum, A.J. Haulcy and Bryce Boettcher each had seven tackles. Justin Walley recorded six tackles. Laiatu Latu had six tackles and half a sack. Arden Key finished with five tackles and half a sack. Adetomiwa Adebawore had four tackles. DeForest Buckner had two tackles and half a sack. Jerry Tillery had three tackles. Charvarius Ward and Tim Smith each had two tackles. Jonathan Owens, Sauce Gardner, Jaylahn Tuimoloau, Kenneth Harris, Tahj Chambers, Luke Rhodes and Grover Stewart each had one tackle, with Stewart also recording half a sack. Caden Curry had one tackle. Spencer Shrader had one field goal and one tackle.

Baltimore will host New Orleans on Sunday, Sept. 20, 2026. Indianapolis will travel to Kansas City on the same date. The Ravens then visit Dallas on Sept. 27, while the Colts host Houston on Sept. 27.

Interstat’s game simulator had projected a final score of Indianapolis 28, Baltimore 25. Interstat’s ELO system gave Baltimore a 62.1 percent probability to win. Indianapolis was installed as a pregame favorite with a spread of minus 3.5. The over/under line was 47.5, and the teams combined for 64 points.