GLENDALE, Ariz. (Interstat) — The San Francisco 49ers look to complete a season sweep and solidify their playoff positioning when they visit the Arizona Cardinals in an NFC West matchup on Sunday.

The 49ers (6-4) enter the contest after a 42-26 home loss to the Los Angeles Rams, a game in which quarterback Mac Jones threw for 319 yards and three touchdowns. Despite the defeat, San Francisco holds a two-game winning streak on the road.

Arizona (3-6) is looking to rebound from a 44-22 loss at Seattle. Quarterback Jacoby Brissett passed for two touchdowns and ran for 31 yards in the defeat.

The Week 3 meeting between these teams was a defensive struggle, with the 49ers edging the Cardinals 16-15 in San Francisco. The Cardinals have lost three of their last four games.

Despite the records, the Cardinals are a 2.5-point favorite at home, according to FanDuel Sportsbook. The over/under is 48.5. Interstat’s game simulator projects a 28-25 Arizona victory.

The game is scheduled for 1:25 p.m. MST at State Farm Stadium.