SANTA CLARA, Calif. (Interstat) — Matthew Stafford passed for four touchdowns and the Los Angeles Rams built a large early lead to defeat the San Francisco 49ers 42-26 on Sunday at Levi’s Stadium. Stafford completed 24 of 36 passes for 280 yards, connecting with Davante Adams, Puka Nacua, Colby Parkinson and Davis Allen for scores. Kyren Williams added two rushing touchdowns for the Rams, who led 21-0 after the first quarter and 28-7 at halftime. The 49ers’ Mac Jones threw for three touchdowns in the loss, but a failed two-point conversion in the fourth quarter sealed the outcome. The Rams improved to 7-2, while the 49ers fell to 6-4. Attendance was 71,239.