CHARLOTTE, N.C. (Interstat) — The struggling New Orleans Saints, mired in an eight-game losing streak, travel to face the surging Carolina Panthers in an NFC South matchup on Sunday, Nov. 9, 2025, at Bank of America Stadium.

The Saints (1-8) are coming off a 34-10 road loss to the Los Angeles Rams, their eighth consecutive defeat since a Week 5 victory. Quarterback Tyler Shough completed 15 of 24 passes for 176 yards and a touchdown in the loss.

Conversely, the Panthers (5-4) are riding a two-game winning streak after a 16-13 victory at Green Bay last week. Quarterback Bryce Young managed the game effectively, and the Carolina defense has been a key factor in its winning record.

Despite the stark contrast in records, the Saints have been installed as a slight 5.5-point favorite by oddsmakers. The over/under is set at 38.5 points. A projection from Interstat, however, forecasts a higher-scoring affair with Carolina winning 32-24.

The game represents a critical juncture for both teams. New Orleans is desperate to salvage its season, while Carolina aims to solidify its position above .500 and remain in the playoff conversation.