ATLANTA (Interstat) — The Buffalo Bills, looking to rebound from their first loss of the season, travel to face the Atlanta Falcons in a Monday night NFL clash on Oct. 13, 2025, at Mercedes-Benz Stadium.

The Bills (4-1) saw their undefeated start end with a 23-20 home loss to the New England Patriots on Oct. 5. Quarterback Josh Allen was productive in the defeat, passing for 253 yards and two touchdowns while adding 53 rushing yards. Prior to that, Buffalo’s offense was potent, averaging over 30 points in wins against New Orleans, Miami, the New York Jets and Baltimore.

The Falcons (2-2) are coming off a 34-27 victory over Washington on Sept. 28. Quarterback Michael Penix Jr. threw for 313 yards and two touchdowns in that win. Atlanta’s season has been marked by inconsistency, sandwiching a 30-0 shutout loss at Carolina between wins over Minnesota and Washington.

Despite Buffalo’s superior record, Atlanta has been installed as a 5.5-point favorite by oddsmakers. The over/under is set at 49.5 points. A projection from Interstat forecasts a 30-24 victory for the Falcons.

The game features a compelling matchup between Buffalo’s dynamic offense, led by Allen, and an Atlanta team seeking to establish momentum. The Falcons will look to capitalize on their home-field advantage before embarking on a tough stretch of their schedule.