MILWAUKEE (Interstat) — Gavin Sheets hit a three-run homer in the top of the ninth inning Wednesday night, lifting the San Diego Padres to a 3-1 victory over the Milwaukee Brewers at American Family Field.

The Padres snapped a 1-1 deadlock with their outburst off Brewers reliever Abner Uribe, who suffered his second loss of the season. Sheets finished 2 for 4 with a home run and three RBIs. Mason Miller earned his 13th save with a scoreless ninth inning, striking out two.

San Diego improved to 25-17, while Milwaukee fell to 23-17. The Brewers had won the series opener Tuesday 6-4.

The game featured a pitchers’ duel for the first eight innings. Milwaukee starter Jacob Misiorowski turned in a dominant performance, allowing four hits and no earned runs over seven innings while striking out 10. He did not factor in the decision. San Diego starter Michael King worked 5 2/3 innings, yielding six hits and one earned run with five strikeouts.

The Brewers took a 1-0 lead in the fifth inning. Sal Frelick led off with a single to right field. Joey Ortiz followed with a bunt single to pitcher Michael King, moving Frelick to second. Jackson Chourio grounded into a force out at second, with Frelick advancing to third. Brice Turang then grounded into a force play that scored Frelick, putting Milwaukee ahead 1-0.

San Diego tied the game in the ninth. Fernando Tatis Jr. grounded out to start the inning, and Manny Machado lined out to right field. Miguel Andujar singled to center off Uribe, and Xander Bogaerts walked. Sheets then drove a 1-1 pitch from Uribe over the wall in right-center field for his sixth homer of the season, scoring Andujar and Bogaerts. The three runs were all San Diego would need.

The Padres threatened earlier against Misiorowski but could not break through. In the second inning, Sheets singled and Ty France singled, putting runners at first and third with two outs, but Rodolfo Durán struck out. In the third, Tatis singled but was stranded. Misiorowski retired 11 of the final 12 batters he faced, striking out five in a row at one point.

Milwaukee also had chances. In the second inning, Garrett Mitchell walked, Luis Rengifo singled and Sal Frelick singled to load the bases with two outs, but Joey Ortiz struck out. In the sixth, Andrew Vaughn singled and Rengifo singled, but Frelick flied out to end the inning. In the eighth, Jake Bauers doubled with one out but was left stranded.

San Diego’s bullpen held the Brewers scoreless over the final 3 1/3 innings. Jason Adam pitched a scoreless eighth inning and earned the win, improving to 2-0. Jeremiah Estrada worked 1 1/3 hitless innings. Miller allowed a one-out single to Rengifo in the ninth but then struck out Sal Frelick, induced a groundout from Gary Sánchez and struck out Chourio to end the game.

Rengifo had three hits for Milwaukee, going 3 for 4. Chourio singled once and walked. Vaughn had a single and Bauers doubled. Turang went 0 for 4 but drove in the Brewers’ only run with a fielder’s choice.

For San Diego, King settled down after the second inning, retiring seven straight batters at one point. He allowed only one run despite giving up six hits and two walks. The Padres defense turned a double play in the seventh when center fielder Jackson Merrill threw out Chourio trying to advance to second on a fly ball.

The game was played in 2 hours, 38 minutes before an announced crowd of 28,683.

San Diego had lost four of its previous five games before Wednesday’s win. Milwaukee had won two straight after taking the series opener.

The Padres and Brewers conclude their two-game series Thursday at American Family Field. San Diego then travels to Seattle for a three-game weekend series against the Mariners. Milwaukee heads to Minnesota for a three-game set against the Twins.

Interstat’s game simulator had projected a final score of Milwaukee 6, San Diego 5, with the Brewers holding a 57.10 percent probability to win according to its ELO system. Milwaukee was installed as a pregame favorite with a spread of minus-1.5. The total score of 4 went over the over-under line of 7.