BOSTON (Interstat) — Zack Wheeler pitched into the seventh inning, Kyle Schwarber hit his 17th home run and the Philadelphia Phillies held off the Boston Red Sox 2-1 on Tuesday night at Fenway Park.

Wheeler allowed one run on five hits over six-plus innings, striking out five and walking none to improve to 2-0. Jhoan Duran earned his sixth save of the season by working a scoreless ninth inning, stranding the tying run at second base.

The Phillies took an early lead and never trailed, though Boston’s bullpen kept the game close. Brayan Bello started for the Red Sox and took a tough loss, allowing one earned run on four hits over six and one-third innings while striking out five. Jovani Morán, who relieved Bello in the seventh, gave up the decisive second run and was charged with the loss, falling to 0-1.

Philadelphia struck first in the opening inning. With one out, Schwarber drove a 1-0 pitch from Bello to right-center field for a solo home run, his 17th of the season. It was the only hit of the inning, as Trea Turner grounded out and Bryce Harper and Adolis García struck out.

The Phillies added another run in the second. Brandon Marsh led off with a single to right, moved to second on a groundout by J.T. Realmuto, and scored on Bryson Stott’s ground-rule double to right field. Stott’s sixth double of the year put Philadelphia ahead 2-0. Alec Bohm flew out and Justin Crawford walked before Trea Turner struck out to end the inning.

Boston mounted its best threat in the seventh. Mickey Gasper led off with a sharp single to right off Wheeler. After Wilyer Abreu flew out and Masataka Yoshida flied out, Trevor Story singled to left, sending Gasper to second. Ceddanne Rafaela followed with a fly-ball single to right, scoring Gasper and cutting the deficit to 2-1. Story advanced to third, but Marcelo Mayer grounded out to shortstop to end the inning.

The Red Sox had a chance in the eighth against Philadelphia’s bullpen. Carlos Narváez singled to right with one out, and after Caleb Durbin flew out, pinch-runner Connor Wong was replaced by Jarren Duran. Duran grounded into a forceout, with shortstop Trea Turner fielding and throwing to second to retire Wong. The Phillies challenged the call, and it was overturned, but Mickey Gasper struck out to strand Duran.

In the ninth, Duran entered and struck out Abreu on a foul tip. Yoshida singled to left, and Trevor Story walked, bringing the tying run to second. But Duran struck out Rafaela swinging and got Mayer to ground out to second to end the game.

Boston’s offense managed seven hits but grounded into two double plays. Marcelo Mayer, Carlos Narváez, Mickey Gasper, Wilyer Abreu, Masataka Yoshida, Trevor Story and Ceddanne Rafaela each had one hit. Jarren Duran went 0 for 4 with two strikeouts and a forceout.

Philadelphia’s five hits included Schwarber’s homer, Stott’s double, and singles by Marsh, Bryson Stott and Alec Bohm. Brandon Marsh also had a single. The Phillies struck out 11 times and walked twice.

Defensively, Philadelphia turned two double plays, one in the second inning when Yoshida was hit by a pitch and then erased on a Trevor Story grounder, and another in the third after a Marcelo Mayer single.

Attendance was 36,795, and the game lasted 2 hours, 29 minutes.

The win lifted Philadelphia to 20-22, while Boston fell to 17-24. The teams continue their series Wednesday and Thursday at Fenway Park before Philadelphia travels to Pittsburgh for a weekend set. Boston heads to Atlanta for three games beginning Friday.

Interstat’s game simulator had projected a final score of Philadelphia Phillies 6, Boston Red Sox 5. Interstat’s ELO system had given Boston a 50.70 percent probability to win. Philadelphia had been installed as a pregame favorite with a spread of minus-1.5. The total of three runs went over the over-under line of 8.5.