SAN FRANCISCO (Interstat) — The first-place San Diego Padres open a three-game series Monday night at Oracle Park against the last-place San Francisco Giants, with first pitch set for 7:15 p.m. PDT.

San Diego (20-13) enters on a high, having taken two of three from the Chicago White Sox at home. The Padres, who lead the National League West by 2 1/2 games, send right-hander Griffin Canning to the mound. Canning (1-0, 1.80 ERA) earned the win in Sunday’s 4-3 decision, tossing five innings of three-hit ball with one earned run and seven strikeouts. He also was the most productive player in that game per the team’s internal metrics.

San Francisco (13-21) has lost six straight — the longest active skid in the majors — after a 2-1, 10-inning defeat at Tampa Bay on Sunday. The Giants’ offense managed just two runs across the three-game series against the Rays. Right-hander Tyler Mahle (2-3, 3.86 ERA) gets the start for San Francisco. Mahle was the losing pitcher Sunday despite a strong outing: 5 1/3 innings, four hits, no earned runs and five strikeouts. He has been inconsistent, however, allowing five earned runs in a loss at Philadelphia on April 28 after tossing seven shutout innings against the Los Angeles Dodgers on April 22.

The teams last met April 1 in San Diego, a 7-1 Padres win. The Giants took the final two games of that three-game set March 30-31, both by one-run margins. Interstat’s game simulator projects a 4-3 final in favor of San Diego.

San Diego third baseman Manny Machado went 2 for 4 with a home run and an RBI in Sunday’s win. The Padres have won four of their last five games.

San Francisco has lost 11 of its last 13. The Giants’ bullpen has been taxed, using five relievers Sunday. Keaton Winn and Matt Gage each threw scoreless frames in the loss.

The series continues Tuesday and Wednesday before both teams head on the road. San Diego travels to St. Louis for four games, while San Francisco visits the Los Angeles Dodgers for three games starting Monday, May 11.