WASHINGTON (Interstat) — Jacob Misiorowski carried a no-hitter into the sixth inning and William Contreras drove in three runs as the Milwaukee Brewers defeated the Washington Nationals 6-1 on Friday night at Nationals Park.

Misiorowski, a 24-year-old right-hander, allowed no hits and struck out eight over 5 1/3 innings, the longest scoreless outing of his young career. He walked two and faced the minimum through five innings before departing after a leadoff walk in the sixth. Milwaukee improved to 17-14 while Washington fell to 15-18 before a crowd of 19,764 in a game that lasted 2 hours, 58 minutes.

The Brewers pounded out 12 hits, including four from Contreras, who singled in the third, fifth, seventh and eighth innings. His final hit, a two-run single in the eighth, broke the game open after the Nationals had pulled within 4-1.

Milwaukee took the lead in the first inning when Garrett Mitchell led off with a double to right field, moved to third on a groundout and was stranded, but the Brewers pushed a run across in the third on Contreras’ single to center that scored David Hamilton, who had walked and advanced on a Brice Turang walk.

The Brewers added two more in the fifth. Turang singled, Contreras singled and Jake Bauers walked to load the bases. Luis Rengifo forced out Bauers at second but brought home Turang. Tyler Black then doubled down the left-field line, scoring Contreras and sending Rengifo to third. The rally ended when Sal Frelick lined out sharply to right.

Washington’s only run came in the seventh. With Milwaukee leading 4-0, Aaron Ashby had replaced Misiorowski and struck out Curtis Mead to start the inning. CJ Abrams walked, and Daylen Lile doubled to put runners at second and third. Brady House grounded out to third, scoring Abrams to make it 4-1. Ashby struck out Joey Wiemer to end the threat.

Milwaukee answered in the eighth. Frelick singled, Blake Perkins reached on a fielder’s choice and advanced to second on a throwing error by second baseman Nasim Nuñez. Hamilton bunted for a single to load the bases. After Mitchell struck out and Turang popped out, Contreras lined a single to right, plating Frelick and Perkins for a 6-1 lead. Bauers walked and Rengifo flied out to end the inning.

The Nationals put two runners on in the eighth on a walk and a single but Ashby induced a groundout to escape. Easton McGee pitched a perfect ninth, striking out one and closing out the victory.

Misiorowski, who improved to 2-2, came off back-to-back losses. He allowed three earned runs in six innings against Pittsburgh on April 25 and one earned run in five innings at Miami on April 19. Against Washington, he dominated with his fastball and slider, recording 12 swinging strikes among his 82 pitches.

Nationals starter Jake Irvin took the loss, dropping to 1-4. He allowed three earned runs on six hits over five innings, striking out five and walking three. Cionel Pérez threw two scoreless innings, and Paxton Schultz and Andre Granillo each tossed a scoreless frame, but the Nationals managed only two hits total.

Washington’s lineup was held in check after scoring five runs in a win at the New York Mets the previous day. The Nationals had won two of three in that series, but their offense could not solve Misiorowski. Curtis Mead drew a walk in the first and Brady House walked in the second, but Misiorowski struck out the side in the second, two in the fifth and one in the sixth before departing.

David Hamilton went 2 for 4 with a walk and a run scored while playing shortstop and later third base. Tyler Black finished 2 for 3 with a double and an RBI. Garrett Mitchell doubled in the first but struck out three times.

The Brewers, who had split a two-game series with Arizona earlier in the week, snapped a two-game losing streak in head-to-head matchups with Washington. The Nationals had swept a three-game series in Milwaukee from April 10-12, outscoring the Brewers 18-10.

Milwaukee’s next game is Saturday afternoon at Nationals Park, followed by a Sunday series finale before the Brewers travel to St. Louis for three games. Washington will continue its homestand with the Brewers on Saturday and Sunday before hosting Minnesota for three.

Interstat’s game simulator had projected a final score of Washington 5, Milwaukee 3. Interstat’s ELO system had given Milwaukee a 63.90 percent probability to win. The Brewers were installed as a pregame favorite with a spread of minus-1.5. The total score of seven went over the over/under line of 8.5.