SAN FRANCISCO (Interstat) — The New York Yankees and San Francisco Giants, both looking to set an early tone for the 2026 season, will open a three-game series at Oracle Park on Wednesday with a marquee pitching matchup featuring Max Fried and Logan Webb.

First pitch is scheduled for 7:15 p.m. PDT.

The game marks the season opener for both clubs. The Yankees, coming off a 5-2 home loss to the Toronto Blue Jays in their final 2025 playoff game on Oct. 8, will send newly acquired ace Max Fried to the mound. The left-hander, who signed with New York in the offseason, will make his Yankees debut.

He will be opposed by Giants stalwart Logan Webb, who closed his 2025 campaign with a four-hit shutout in a 4-0 win over the Colorado Rockies on Sept. 28. The duel between Fried and Webb projects as a low-scoring affair. The Interstat game simulator predicts a 2-1 victory for the visiting Yankees.

The series opener begins a challenging early stretch for both teams. Following this set, the Yankees continue a West Coast trip with three games in Seattle before returning home. The Giants, after hosting New York, will embark on a road trip to San Diego before returning to face the New York Mets and Philadelphia Phillies.

Wednesday’s game will be the first regular-season meeting between the historic franchises since 2022. With Fried and Webb, two of the league’s premier ground-ball pitchers, on the hill, offense may be at a premium. The outcome could hinge on which ace better navigates a lineup facing its first live action of the new season.

The forecast for San Francisco calls for clear skies and temperatures in the low 60s at game time.