MADRID (Interstat) — Real Madrid looks to avenge its only league loss this season when it visits Athletic Bilbao in a key La Liga match on Wednesday.

The matchup at San Mames is a rematch of Bilbao’s 1-0 home victory over Madrid on Oct. 18, which stands as the defending champion’s sole domestic defeat. Carlo Ancelotti’s side arrives after a 1-1 draw at Girona last Sunday, a result that snapped a three-game winning streak across all competitions. Madrid’s recent league form has been inconsistent, with two draws in its last three matches.

Athletic, under manager Ernesto Valverde, is buoyed by a 2-0 win at Levante last Saturday. Its form has been mixed, however, with a 4-0 loss at Barcelona preceding the victory. The Basque club has proven a tough opponent at home, where it has already beaten Madrid this campaign.

According to Interstat’s game simulator, the projected final score is Real Madrid 2, Athletic Bilbao 1.

A win for Madrid would apply pressure at the top of the table, while Bilbao seeks a rare league double over the powerhouse to bolster its European qualification hopes. The visitors will be without defender David Alaba, who is out with a long-term knee injury. Bilbao reports a full squad available.

Following this match, Real Madrid hosts Celta Vigo on Sunday. Athletic Bilbao faces a quick turnaround, hosting Atletico Madrid next Saturday.