- 2026-12-13 in 1mo St. Louis Rams at San Francisco 49ers
- 2026-09-10 1mo San Francisco 49ers 27 at St. Louis Rams 7
- 2025-11-09 11mo St. Louis Rams 42 at San Francisco 49ers 26 Matthew Stafford LAR 24/36-280yd 4td
- 2025-10-02 1y San Francisco 49ers 26 at St. Louis Rams 23 Mac Jones SFF 33/49-342yd 4run-5yd 2td
- 2024-12-12 1y St. Louis Rams 12 at San Francisco 49ers 6 Matthew Stafford LAR 16/27-160yd 4run-18yd
- 2024-09-22 2y San Francisco 49ers 24 at St. Louis Rams 27 Matthew Stafford LAR 16/25-221yd 1td
- 2024-01-07 2y St. Louis Rams 21 at San Francisco 49ers 20 Carson Wentz LAR 17/24-163yd 17run-56yd 2td 1td
- 2023-09-17 3y San Francisco 49ers 30 at St. Louis Rams 23 Brock Purdy SFF 17/25-206yd 3run-5yd 1td
- 2022-10-30 3y San Francisco 49ers 31 at St. Louis Rams 14 Jimmy Garoppolo SFF 21/25-235yd 1run-3yd 2td
- 2022-10-03 4y St. Louis Rams 9 at San Francisco 49ers 24 Jimmy Garoppolo SFF 16/27-239yd 1run-3yd 1td
- 2022-01-30 4y San Francisco 49ers 17 at St. Louis Rams 20 Matthew Stafford LAR 31/45-337yd 5run-8yd 2td
- 2022-01-09 4y San Francisco 49ers 27 at St. Louis Rams 24 Jimmy Garoppolo SFF 23/32-316yd 1run-1yd 1td
- 2021-11-15 4y St. Louis Rams 10 at San Francisco 49ers 31 Jimmy Garoppolo SFF 15/19-182yd 2run-1yd 2td
- 2020-11-29 5y San Francisco 49ers 23 at St. Louis Rams 20 Nick Mullens SFF 24/35-252yd
- 2020-10-18 5y St. Louis Rams 16 at San Francisco 49ers 24 Jimmy Garoppolo SFF 23/33-268yd 4run-8yd 3td
- 2019-12-21 6y St. Louis Rams 31 at San Francisco 49ers 34 Jimmy Garoppolo SFF 16/27-248yd 4run-5yd 1td
- 2019-10-13 7y San Francisco 49ers 20 at St. Louis Rams 7 Jimmy Garoppolo SFF 24/33-243yd 5run-4yd 1td
- 2018-12-30 7y San Francisco 49ers 32 at St. Louis Rams 48 Jared Goff LAR 15/26-199yd 4td
- 2018-10-21 7y St. Louis Rams 39 at San Francisco 49ers 10 Jared Goff LAR 18/24-202yd 3run-4yd 2td
- 2017-12-31 8y San Francisco 49ers 34 at St. Louis Rams 13 Jimmy Garoppolo SFF 20/33-292yd 1tck 2td
- 2017-09-21 9y St. Louis Rams 41 at San Francisco 49ers 39 Jared Goff LAR 22/28-292yd 3td
- 2016-12-24 9y San Francisco 49ers 22 at St. Louis Rams 21 Colin Kaepernick SFF 28/37-266yd 6run-15yd 2td 1td
- 2016-09-12 10y St. Louis Rams 0 at San Francisco 49ers 28 Blaine Gabbert SFF 22/35-170yd 9run-43yd 1rec--16yd 1td
- 2016-01-03 10y St. Louis Rams 16 at San Francisco 49ers 19 Blaine Gabbert SFF 28/44-354yd 7run-7yd 1td
- 2015-11-01 10y San Francisco 49ers 6 at St. Louis Rams 27 Nick Foles STL 14/23-191yd 1td
- 2014-11-02 11y St. Louis Rams 13 at San Francisco 49ers 10 Austin Davis STL 13/24-105yd 2run-9yd 1td
- 2014-10-13 12y San Francisco 49ers 31 at St. Louis Rams 17 Colin Kaepernick SFF 22/35-343yd 3run-37yd 3td
- 2013-12-01 12y St. Louis Rams 13 at San Francisco 49ers 23 Colin Kaepernick SFF 19/28-275yd 4run-21yd 1td
- 2013-09-26 13y San Francisco 49ers 35 at St. Louis Rams 11 Colin Kaepernick SFF 15/23-167yd 3run-11yd 2td
- 2012-12-02 13y San Francisco 49ers 13 at St. Louis Rams 16 Sam Bradford STL 26/39-221yd 3run-31yd
- 2012-11-11 13y St. Louis Rams 24 at San Francisco 49ers 24 Colin Kaepernick SFF 11/17-117yd 8run-66yd 1td
- 2012-01-01 14y San Francisco 49ers 34 at St. Louis Rams 27 Alex Smith SFF 20/30-213yd 5run-4yd 1td 1td
- 2011-12-04 14y St. Louis Rams 0 at San Francisco 49ers 26 Alex Smith SFF 17/23-274yd 2run-10yd 2td
- 2010-12-26 15y San Francisco 49ers 17 at St. Louis Rams 25 Sam Bradford STL 28/37-292yd 1td
- 2010-11-14 15y St. Louis Rams 20 at San Francisco 49ers 23 Troy Smith SFF 17/28-356yd 3run-12yd 1td
- 2010-01-03 16y San Francisco 49ers 28 at St. Louis Rams 6 Alex Smith SFF 17/28-222yd 4run-1yd 1td
- 2009-10-04 17y St. Louis Rams 0 at San Francisco 49ers 35 Shaun Hill SFF 14/24-152yd 2td
- 2008-12-21 17y San Francisco 49ers 17 at St. Louis Rams 16 Shaun Hill SFF 18/34-216yd 4run-45yd 2td
- 2008-11-16 17y St. Louis Rams 16 at San Francisco 49ers 35 Shaun Hill SFF 15/20-213yd 3run-5yd 2td 1td
- 2007-11-18 18y St. Louis Rams 13 at San Francisco 49ers 9 Steven Jackson STL 23run-92yd 4rec-20yd
- 2007-09-16 19y San Francisco 49ers 17 at St. Louis Rams 16 Alex Smith SFF 11/17-126yd
- 2006-11-26 19y San Francisco 49ers 17 at St. Louis Rams 20 Marc Bulger STL 23/34-201yd 1td
- 2006-09-17 20y St. Louis Rams 13 at San Francisco 49ers 20 Alex Smith SFF 11/22-233yd 1td
- 2005-12-24 20y San Francisco 49ers 24 at St. Louis Rams 20 Alex Smith SFF 12/16-131yd 7run-21yd
- 2005-09-11 21y St. Louis Rams 25 at San Francisco 49ers 28 Tim Rattay SFF 11/16-165yd 2td
- 2004-12-05 21y San Francisco 49ers 6 at St. Louis Rams 16 Chris Chandler STL 18/27-216yd 1td
- 2004-10-03 22y St. Louis Rams 24 at San Francisco 49ers 14 Marc Bulger STL 17/25-186yd 2run-5yd 1td
- 2003-11-02 22y St. Louis Rams 10 at San Francisco 49ers 30 Tim Rattay SFF 19/29-236yd 3run-4yd 3td
- 2003-09-14 23y San Francisco 49ers 24 at St. Louis Rams 27 Marc Bulger STL 25/36-236yd 2td
- 2002-12-30 23y San Francisco 49ers 20 at St. Louis Rams 31 Jamie Martin STL 22/35-245yd 3td