INGLEWOOD, Calif. (Interstat) — The New York Giants will visit the Los Angeles Rams in a National Football League game Monday, Sept. 21, 2026, at SoFi Stadium in Inglewood, California. The Giants enter with a 1-0 record, and the Rams are 0-1.

New York opened the season with a 28-20 home win over Dallas on Sunday, Sept. 13. Quarterback Jaxson Dart completed 23 of 29 passes for 230 yards and rushed 11 times for 54 yards, accounting for three touchdowns. Cam Skattebo added 18 carries for 81 yards and one touchdown. Devin Singletary had six carries for 16 yards and four receptions for 22 yards and one touchdown. Dart is the player to watch for the Giants as they seek a 2-0 start.

Los Angeles is coming off a 27-7 home loss to San Francisco on Thursday, Sept. 10. Matthew Stafford, Stetson Bennett IV and Blake Corum were listed among the Rams’ most productive players in the defeat. Los Angeles will try to even its record and avoid a second straight home loss to open the season.

After this game, the Giants are scheduled to host Tennessee on Sunday, Sept. 27, and Arizona on Sunday, Oct. 4. New York will then visit Washington on Sunday, Oct. 11, host New Orleans on Sunday, Oct. 18, and visit Houston on Sunday, Oct. 25. Later matchups include a trip to Philadelphia on Nov. 8, a home game against Washington on Thursday, Nov. 12, a home game against Jacksonville on Nov. 22, a visit to Indianapolis on Nov. 29, and a home game against San Francisco on Dec. 6.

The Rams will travel to Denver on Sunday, Sept. 27, and to Philadelphia on Sunday, Oct. 4. Los Angeles will host Buffalo on Monday, Oct. 12, and Arizona on Sunday, Oct. 18. The Rams will then visit Las Vegas on Oct. 25 and host the L.A. Chargers on Nov. 1. Los Angeles will visit Washington on Nov. 8, visit Arizona on Nov. 15, host Green Bay on Wednesday, Nov. 25, and host Kansas City on Thursday, Dec. 3.

The Giants are the visiting team, and the Rams are the home team in the NFL contest. New York carries a 1-0 record into the game, while Los Angeles is 0-1.

Interstat’s game simulator projects a final score of Los Angeles Rams 28, New York Giants 21. The Giants have been installed as a pregame favorite with a spread of +7. The over/under for the game is 47.5.