KANSAS CITY (Interstat) — The Indianapolis Colts will travel to face the Kansas City Chiefs on Sunday, Sept. 20, 2026, in a National Football League game at GEHA Field at Arrowhead Stadium. The forecast for game time calls for 81 degrees and rain. Indianapolis enters at 0-1, while Kansas City enters at 1-0.

The Colts opened the season with a 41-23 home loss to Baltimore on Sept. 13. Quarterback Daniel Jones completed 19 of 31 passes for 166 yards and a touchdown and added one run for 4 yards. Running back Jonathan Taylor produced 98 yards on 19 carries, caught three passes for 23 yards and scored twice. Wide receiver Alec Pierce had four receptions for 61 yards. Jones is the player to watch for Indianapolis as the Colts seek their first win.

The Chiefs beat Denver 31-10 at home on Sept. 14. Quarterback Patrick Mahomes completed 15 of 27 passes for 184 yards and two touchdowns and rushed seven times for 23 yards and another score. Running back Kenneth Walker III had 23 carries for 173 yards and a touchdown and added three catches for 18 yards and a score. Emmett Johnson contributed 24 rushing yards, 44 receiving yards and a tackle. Mahomes is the player to watch for Kansas City.

The matchup pairs an Indianapolis offense trying to build consistency against a Kansas City team that opened with a strong home performance. The Colts will need to limit Kansas City’s possessions and protect the football. The Chiefs will look to use their home crowd and the wet conditions. Both teams are beginning a stretch of conference and interconference play.

After this game, Indianapolis will host Houston on Sept. 27. Kansas City will travel to Miami on Sept. 27. The Colts then visit Washington on Oct. 4 and Pittsburgh on Oct. 11 before hosting Tennessee on Oct. 18. They visit Minnesota on Oct. 25, play at Jacksonville on Nov. 1, host Dallas on Nov. 8 and Miami on Nov. 15, visit Houston on Nov. 19 and host the New York Giants on Nov. 29.

The Chiefs visit Las Vegas on Oct. 4, host the Los Angeles Chargers on Oct. 18, visit Seattle on Oct. 25 and Denver on Nov. 1, host the New York Jets on Nov. 8, visit Atlanta on Nov. 15, host Arizona on Nov. 22, visit Buffalo on Nov. 26 and visit the Los Angeles Rams on Dec. 3.

Interstat’s game simulator projects Kansas City 32, Indianapolis 22. Interstat’s ELO system gives Kansas City an 85 percent probability to win. The pregame spread is Indianapolis +6, and the over/under is 46.5.