INGLEWOOD, Calif. (Interstat) — Jacoby Brissett threw for 277 yards and a touchdown, Chad Ryland kicked four field goals, and the Arizona Cardinals opened the NFL season with a 26-14 victory over the Los Angeles Chargers on Sunday, Sept. 13, 2026, at SoFi Stadium. The game was a National Football League regular-season matchup. Arizona was the visiting team, and the Chargers were the home team. The Cardinals improved to 1-0. The Chargers fell to 0-1 before an announced attendance of 70,540.

Arizona struck first in the opening quarter when Jeremiyah Love ran left end for a 5-yard touchdown with 8:49 remaining. Ryland’s extra point made it 7-0. The Chargers answered at 4:22 of the first quarter when Omarion Hampton scored on an 8-yard run up the middle, and Cameron Dicker’s extra point tied the game at 7-7.

Ryland put Arizona back ahead with a 27-yard field goal with 6:51 left in the second quarter. As the second quarter expired, Ryland connected from 44 yards to send Arizona into halftime with a 13-7 lead. In the third quarter, Ryland made a 34-yard field goal with 7:25 remaining to extend the margin to 16-7. The Chargers responded at 6:03 of the third when Justin Herbert threw a short right pass to Ladd McConkey for an 8-yard touchdown. Dicker’s extra point cut Arizona’s lead to 16-14.

Arizona regained control in the fourth quarter. Brissett threw a short left pass to Trey McBride for a 3-yard touchdown with 11:44 remaining, and Ryland’s extra point made it 23-14. Ryland capped the scoring with a 49-yard field goal with 2:33 left, securing the 26-14 final. The Chargers did not score again after McConkey’s touchdown.

Brissett was Arizona’s top star. The 6-foot-4, 235-pound quarterback from West Palm Beach, Florida, completed 27 of 37 passes for 277 yards and one touchdown. He also ran six times for 14 yards.

Herbert, a 6-foot-6, 236-pound quarterback from Eugene, Oregon, completed 17 of 27 passes for 209 yards and one touchdown for Los Angeles. He ran five times for 29 yards. McConkey caught five passes for 82 yards and one touchdown. David Njoku added five receptions for 58 yards, Oronde Gadsden had two catches for 32 yards, Tre’ Harris had three receptions for 20 yards, and Quentin Johnston finished with two catches for 17 yards.

Hampton led the Chargers’ rushing attack with 12 carries for 43 yards and one touchdown. Keaton Mitchell ran four times for 9 yards and returned two kickoffs for 47 yards. Derius Davis returned two kickoffs for 33 yards and made one tackle. Cameron Dicker made both of his extra-point attempts. JK Scott punted twice for 99 yards.

Arizona’s ground game was led by Tyler Allgeier, who ran 17 times for 61 yards and caught two passes for 9 yards. Jeremiyah Love added 11 carries for 41 yards and two receptions for 9 yards to go with his touchdown. McBride caught nine passes for 95 yards and one touchdown. Kendrick Bourne had eight receptions for 75 yards, Michael Wilson caught five passes for 56 yards, and Marvin Harrison Jr. had one reception for 33 yards. Blake Gillikin punted three times for 158 yards.

Troy Dye led Los Angeles with five tackles and half a sack. Derwin James Jr. made 10 tackles. Daiyan Henley recorded eight tackles and half a sack. Cam Hart and Del’Shawn Phillips each made six tackles. Genesis Smith, Elijah Molden, Tuli Tuipulotu, and Jamaree Caldwell each had five tackles. Dalvin Tomlinson finished with four tackles. Tony Jefferson, Tarheeb Still, and Justin Eboigbe each made three tackles. Donte Jackson, Khalil Mack, Bud Dupree, Teair Tart, and Akheem Mesidor each had two tackles.

Arizona’s defense was paced by Jack Gibbens, who made seven tackles and half a sack. Mack Wilson Sr. had six tackles. Budda Baker recorded five tackles and half a sack. Jordan Burch made three tackles and one sack. Will Johnson, Denzel Burke, Andrew Wingard, and Roy Lopez each had four tackles. Wingard also intercepted a pass. Zaven Collins and Kitan Crawford each made three tackles. Karson Sharar and Josh Sweat each finished with two tackles. Chad Ryland made four of five field-goal attempts for Arizona.

Arizona’s next 10 games are scheduled as follows: Seattle at Arizona on Sunday, Sept. 20, 2026; Arizona at San Francisco on Sunday, Sept. 27, 2026; Arizona at the New York Giants on Sunday, Oct. 4, 2026; Detroit at Arizona on Sunday, Oct. 11, 2026; Arizona at the Los Angeles Rams on Sunday, Oct. 18, 2026; Denver at Arizona on Sunday, Oct. 25, 2026; Arizona at Dallas on Sunday, Nov. 1, 2026; Arizona at Seattle on Sunday, Nov. 8, 2026; the Los Angeles Rams at Arizona on Sunday, Nov. 15, 2026; and Arizona at Kansas City on Sunday, Nov. 22, 2026.

The Chargers’ next 10 games are Las Vegas at the Los Angeles Chargers on Sunday, Sept. 20, 2026; the Los Angeles Chargers at Buffalo on Sunday, Sept. 27, 2026; the Los Angeles Chargers at Seattle on Sunday, Oct. 4, 2026; Denver at the Los Angeles Chargers on Sunday, Oct. 11, 2026; the Los Angeles Chargers at Kansas City on Sunday, Oct. 18, 2026; the Los Angeles Chargers at the Los Angeles Rams on Sunday, Nov. 1, 2026; Houston at the Los Angeles Chargers on Sunday, Nov. 8, 2026; the Los Angeles Chargers at Baltimore on Monday, Nov. 16, 2026; the New York Jets at the Los Angeles Chargers on Sunday, Nov. 22, 2026; and New England at the Los Angeles Chargers on Sunday, Nov. 29, 2026.

Interstat’s game simulator had projected a final score of Los Angeles Chargers 32, Arizona 21. Interstat’s ELO system had projected Los Angeles Chargers with a 91.3 percent probability to win. Arizona had been installed as a pregame favorite with a spread of +9.5. The total score of 40 went over the over/under line of 47.5.