INDIANAPOLIS (Interstat) — A surging Jacksonville Jaguars squad, riding a four-game win streak, will look to clinch the AFC South title when they visit the Indianapolis Colts at Lucas Oil Stadium on Sunday, Dec. 28, 2025.

The Jaguars (11-4) can secure the division crown with a victory. They have been dominant during their streak, outscoring opponents 143-62, and are coming off a 34-20 road win over Denver. Quarterback Trevor Lawrence is playing at an MVP level, accounting for 12 touchdowns (10 passing, two rushing) in the last four games. In the Week 14 meeting between these teams, a 36-19 Jacksonville win, Lawrence threw for 244 yards and two scores.

The Colts (8-7), meanwhile, have lost three straight and are clinging to faint playoff hopes. Their defense has been porous, allowing an average of 31 points during the skid, including a 48-27 home loss to San Francisco last Monday. Veteran quarterback Philip Rivers passed for 277 yards and two touchdowns in that defeat but will need a more efficient performance against a confident Jacksonville defense.

Despite recent form, oddsmakers favor the Colts by 5.5 points, with an over/under set at 48.5. Interstat’s game simulator projects a 33-22 Indianapolis victory, a prediction that contradicts both the teams’ current trajectories and their head-to-head result from earlier this month.

The Jaguars’ offense, fueled by Lawrence and running back Travis Etienne Jr., will test a Colts run defense that has struggled. Indianapolis will counter with its own ground game led by Jonathan Taylor, who scored in the previous matchup.

A Jacksonville win seals the division and strengthens its positioning for a first-round playoff bye. For Indianapolis, the game is a must-win to keep its postseason aspirations viable ahead of a Week 18 finale at Houston. Kickoff is set for 1 p.m. EST.