INDIANAPOLIS (Interstat) — Brock Purdy threw five touchdown passes and the San Francisco 49ers dominated the Indianapolis Colts 48 to 27 on Monday night at Lucas Oil Stadium. Purdy completed 25 of 34 passes for 295 yards, connecting with Christian McCaffrey and George Kittle among others as the 49ers scored on their first three drives before a crowd of 66,265. The Colts’ Philip Rivers passed for 277 yards and two scores to Alec Pierce, but a fourth-quarter interception returned 74 yards for a touchdown by San Francisco’s Dee Winters sealed the outcome. The 49ers improved to 11-4, while the Colts fell to 8-7.