SANTA CLARA, Calif. (Interstat) — A pivotal NFC clash is set for Monday night as the San Francisco 49ers host the Carolina Panthers at Levi’s Stadium on Nov. 24, 2025.

Both teams enter the contest with winning records and momentum from offensive outbursts in their previous games. The Panthers (6-5) are coming off a 30-27 overtime victory at Atlanta, where quarterback Bryce Young threw for 448 yards and three touchdowns. The 49ers (7-4) are riding high after a 41-22 road win against Arizona, powered by a balanced attack from quarterback Brock Purdy and running back Christian McCaffrey.

The game features a contrast in recent trends. Carolina has shown resilience, winning two of its last three games, though its performance has been inconsistent. San Francisco has been strong at home this season, with its only loss at Levi’s Stadium coming in a 42-26 defeat to the Los Angeles Rams on Nov. 9.

Despite Carolina’s recent success, statistical models and oddsmakers favor the home team. Interstat’s game simulator projects a 33-22 victory for the 49ers. Carolina has been installed as a 7-point underdog, with the over/under for the game set at 49.5 points.

The matchup will be a test for a Panthers defense tasked with containing the 49ers’ multifaceted offense, while Young will look to continue his hot hand against a San Francisco defense looking to rebound from its last home outing. The result could have significant implications for the NFC playoff picture as the season enters its final stretch.