PITTSBURGH (Interstat) — The St. Louis Cardinals will visit the Pittsburgh Pirates on Wednesday, Sept. 23, 2026, at PNC Park. The forecast calls for a game-time temperature near 60 degrees Fahrenheit. St. Louis is the visiting team, and Pittsburgh is the home team.

St. Louis enters at 76-81. Pittsburgh enters at 80-77. The Cardinals’ probable starter is Matthew Liberatore, who has a 5-14 season record. Pittsburgh’s listed player to watch is Jared Jones. St. Louis’s listed player to watch is Andre Pallante.

Pallante last pitched Tuesday at Pittsburgh and took the loss after allowing one earned run on three hits in six innings. He walked two and struck out two. He also pitched Sept. 15 against San Francisco, allowing six earned runs on eight hits in five innings with two walks and two strikeouts. On Sept. 9 at San Francisco, he allowed one earned run on five hits in five innings and struck out four.

Jones pitched Tuesday against St. Louis and earned the win after throwing seven scoreless innings. He allowed one hit and struck out nine. On Sept. 16 against Milwaukee, he allowed three earned runs on seven hits in five innings and struck out nine. On Sept. 10 at the Chicago White Sox, he threw seven scoreless innings, allowed one hit and struck out eight. On Aug. 28 at St. Louis, he allowed three earned runs on seven hits in 4.2 innings and struck out six.

Pittsburgh won the most recent meeting, 2-0, on Tuesday at PNC Park. Tuesday’s game was the first of the current series. The Pirates have won two straight in the series and five of the last seven. In Tuesday’s game, Pallante, Cade Winquest and Justin Bruihl were among St. Louis’s most productive players. Jones, Gregory Soto and Luke Weaver were among Pittsburgh’s most productive players.

St. Louis has lost six of its last 10, including a 5-3 home win over Washington on Sunday. Pittsburgh has won five of its last six, including a 4-3 home win over Kansas City on Sunday. The Pirates have won six of their last 10.

After this game, St. Louis is scheduled to play at Pittsburgh on Thursday before a weekend series at Milwaukee. Pittsburgh is scheduled to host St. Louis on Thursday before a weekend series at Detroit.

Interstat’s game simulator projects a final score of Pittsburgh 8, St. Louis 4. Interstat’s ELO system gives Pittsburgh a 54.6 percent probability to win. St. Louis has been installed as a pregame favorite with a spread of -1.5. The over/under for the game is 7.5.