BOSTON (Interstat) — The Cleveland Guardians will continue a series against the Boston Red Sox on Wednesday, Sept. 23, 2026, at Fenway Park. The game-time forecast calls for 57 degrees. Boston enters at 84-73, while Cleveland is 82-75. The Red Sox are the home team.

Cleveland’s probable pitcher is Foster Griffin (15-5), while Sonny Gray (17-5) is the probable pitcher for Boston. Parker Messick is a player to watch for the Guardians. Messick worked five innings in Tuesday’s 3-2 win at Boston, allowing one earned run on five hits with one walk and five strikeouts. He allowed one earned run over 5 1/3 innings at Minnesota on Sept. 11 and struck out 12 over six innings against Detroit on Sept. 5. He also threw six innings of one-earned-run ball against Kansas City on Aug. 30. Over his past five starts, Messick has allowed three earned runs or fewer each time and has recorded at least five strikeouts in every outing.

Payton Tolle is a player to watch for Boston. Tolle took the loss Tuesday despite giving up two earned runs over 5 2/3 innings with five strikeouts. He struck out 12 over six innings at Baltimore on Sept. 6 and tossed six scoreless innings against Kansas City on Sept. 13. Tolle has allowed two earned runs or fewer in each of his past three starts.

Cleveland won the series opener 3-2 on Tuesday. Messick contributed on the mound, while Cade Smith and Erik Sabrowski each worked a scoreless inning of relief. Boston’s Adley Rutschman went 3 for 4 in the loss. In the teams’ previous meetings this season, Boston won 9-4 on May 31 and 9-1 on May 30, while Cleveland won 4-3 on May 29.

Cleveland has won six of its past 10 games. The Guardians beat the Athletics 1-0 on Sept. 20, 12-6 on Sept. 19 and 5-3 on Sept. 18. They also took two of three from the Chicago White Sox before splitting a series at Minnesota. Boston has lost four of its past 10, including two of three at Tampa Bay last weekend. The Red Sox beat Texas 4-3 on Sept. 17 but dropped the other two games in that series.

The series continues Thursday at Fenway Park before Cleveland travels to Kansas City and Boston hosts the Chicago Cubs.

Interstat’s game simulator projects a final score of Cleveland 8, Boston 7. Interstat’s ELO system gives Boston a 58.1 percent probability to win. Boston has been installed as a -1.5 pregame favorite, and the over/under is 7.5.