ST. LOUIS, Mo. (Interstat) — Drew Gilbert hit a tiebreaking, two-run homer in the 10th inning, and the San Francisco Giants beat the St. Louis Cardinals 6-5 in 10 innings on Wednesday afternoon, Sept. 16, 2026, at Busch Stadium III. San Francisco improved to 64-89. St. Louis fell to 75-78. Anthony Molina allowed two hits over 5 2/3 scoreless innings with six strikeouts for San Francisco. Matthew Liberatore gave up one earned run and six hits over six innings with two strikeouts for St. Louis. Reiver Sanmartin earned the win, Riley O’Brien took the loss, and Joel Kuhnel recorded his eighth save. Jonah Cox went 3 for 4 with an RBI. Brett Harris grounded into a double play that scored Jonah Cox, Andrew Knizner singled in a run, and Gilbert’s homer scored Grant McCray. The Cardinals tied it in the ninth on Leo Bernal’s RBI single and later added a run on Thomas Saggese’s sacrifice fly in the 10th. San Francisco finished with 13 hits to five for St. Louis. St. Louis made two sacrifice flies. San Francisco grounded into two double plays. Attendance was 24,960. Time of game was 3:14.