ST. LOUIS (Interstat) — Randal Grichuk hit a two-out, two-strike, two-run home run in the ninth inning, sending the Chicago White Sox past the St. Louis Cardinals 6-5 on Saturday, Sept. 12, 2026, at Busch Stadium III. The White Sox improved to 76-72. The Cardinals dropped to 73-76. Jordan Hicks earned the win in relief to move to 3-2. Riley O’Brien took the loss and fell to 3-8. Bryan Hudson recorded his eighth save. The game drew 40,387 and lasted 3 hours, 11 minutes.

Chicago’s Sean Newcomb struck out four over 1.1 innings but allowed one earned run. The White Sox bullpen then delivered a series of scoreless appearances. Hagen Smith worked two hitless innings with three strikeouts. Jordan Hicks got the final out of the eighth with the bases loaded and was credited with the win. Bryan Hudson closed the ninth without allowing a hit or run, striking out one. St. Louis starter Kyle Leahy was sharp over three scoreless innings, allowing two hits and striking out four. Luis Gastelum followed with 1.1 scoreless innings, and Justin Bruihl and George Soriano each added scoreless relief. Riley O’Brien could not hold the ninth.

St. Louis built an early 3-0 lead. Masyn Winn delivered a two-run double, and José Fermín added a sacrifice fly. Nathan Church also contributed throughout the night, finishing 3-for-4 with one RBI. Chicago began its comeback with a run on Colson Montgomery’s bases-loaded walk, which forced in Munetaka Murakami. The Cardinals answered when Church doubled sharply to right field, scoring Nolan Gorman. That restored a three-run cushion.

The White Sox responded with three runs to tie the game. Munetaka Murakami walked with the bases loaded to score Sam Antonacci. Kyle Teel then scored on Randal Grichuk’s double-play grounder. Tristan Peters followed with a line-drive single to center field that scored Miguel Vargas. Peters was thrown out trying to stretch the hit into a double, but the game was tied 4-4. Chicago had chances earlier as well. Sam Antonacci singled in the first and third. Miguel Vargas added a single in the fifth. Colson Montgomery reached base multiple times, drawing walks and getting hit by a pitch. Braden Montgomery also reached on a fielder’s choice and later walked. Chase Meidroth walked and struck out. The White Sox left runners on base in several innings before breaking through late.

St. Louis had its own opportunities. Alec Burleson walked in the first and later struck out. Nolan Gorman singled and scored, walked, and struck out. Thomas Saggese singled and scored. Masyn Winn doubled, singled, and scored. Nathan Church singled, doubled, singled, and drove in a run. José Fermín had a sacrifice fly and two walks. Iván Herrera walked twice and lined out with the bases loaded in the eighth. The Cardinals stranded multiple runners in the fourth and eighth.

Both bullpens held firm into the late innings. Hagen Smith pitched two scoreless innings for Chicago, striking out three. Kyle Leahy started for St. Louis and worked three scoreless innings, allowing two hits and striking out four. Luis Gastelum followed with 1.1 scoreless innings. Justin Bruihl and George Soriano each added scoreless relief for the Cardinals. Sean Newcomb struck out four over 1.1 innings for Chicago but allowed one earned run.

The Cardinals moved back in front in the eighth. Leo Bernal led off with a home run to right-center field off Grant Taylor, giving St. Louis a 5-4 lead. Chicago’s bullpen prevented further damage. Jordan Hicks entered and induced Iván Herrera to line out to right field with the bases loaded, ending the inning. Hicks got the win for his brief but critical work.

In the ninth, O’Brien walked Kyle Teel, then struck out Miguel Vargas and Munetaka Murakami. Brenton Doyle pinch-ran for Teel and stole second on a pitchout. With two outs, Grichuk drove a sinker over the right-field fence for a two-run homer. It was his 13th home run of the season and gave Chicago a 6-5 lead. Grichuk finished 1-for-4 with one home run and two RBIs. Peters then grounded out to end the top half.

Bryan Hudson closed the game in the bottom of the ninth. He retired Alec Burleson on a soft lineout to third, struck out Jordan Walker, and got Bernal to ground out to shortstop Luisangel Acuña. Hudson earned the save with a scoreless inning and one strikeout. The White Sox won despite being out-hit 8-6. Chicago also benefited from seven walks and three hit batters. St. Louis pitchers combined for 19 strikes, 58 balls and 19 balls in play. Chicago pitchers combined for 17 strikes, 61 balls and 17 balls in play.

Key performers included Leahy, who allowed two hits and no earned runs over three innings with four strikeouts. Hagen Smith allowed no hits and no earned runs over two innings with three strikeouts. Hudson pitched a scoreless ninth with one strikeout. Gastelum allowed one hit in 1.1 scoreless innings. Grichuk had the decisive homer and two RBIs. Newcomb struck out four in 1.1 innings while allowing one earned run. Hicks recorded one out without allowing a hit or run. Church went 3-for-4 with one RBI for St. Louis. Bruihl and Soriano each delivered scoreless relief. Soriano struck out one in a scoreless inning. Bruihl struck out one in two-thirds of an inning.

The previous night, St. Louis beat Chicago 7-3 at Busch Stadium III. The White Sox had lost four of five entering Saturday. The Cardinals had dropped six of eight. Chicago’s victory helped steady a rocky stretch. The White Sox and Cardinals will conclude their series Sunday in St. Louis. Chicago will then travel to Cleveland for a three-game series beginning Monday. St. Louis will host San Francisco for a three-game series starting Monday.

Interstat’s game simulator projected a final score of Chicago White Sox 4, St. Louis Cardinals 3. Interstat’s ELO system gave St. Louis a 55.2 percent probability to win before the game. Chicago was installed as a pregame favorite with a spread of -1.5. The over/under line was 8.5. The total score was 11.