CINCINNATI, Ohio (Interstat) — Fernando Tatis Jr. homered twice, but the San Diego Padres fell to the Cincinnati Reds 4-3 on Tuesday.

Nick Lodolo allowed two earned runs over six innings and struck out five for Cincinnati. San Diego took an early lead on Manny Machado’s sacrifice fly in the first, but JJ Bleday answered with an RBI single for Cincinnati. Tatis put the Padres up 2-1 with a fifth-inning homer, and Héctor Rodríguez’s RBI single tied it again in the bottom half.

Cincinnati’s two-run eighth proved decisive. José Trevino singled in Elly De La Cruz, and Juan Brito’s sacrifice fly scored Sal Stewart. Tatis homered again in the ninth off Emilio Pagán, who still earned his 20th save. Brock Burke pitched a scoreless inning for the win. Adrian Morejon took the loss.

Randy Vásquez started for San Diego, allowing two earned runs in 4 2/3 innings. Tatis finished 2 for 5 with two RBIs, and Samad Taylor went 2 for 4. The Reds outhit the Padres 8-7 before 19,376 at Great American Ball Park. Game time was 2:47. Cincinnati improved to 66-76, while San Diego dropped to 73-66.