SAN DIEGO (Interstat) — The San Diego Padres matched their season high with 12 hits and rode a dominant effort from a trio of relievers to blank the San Francisco Giants 7-0 on Friday night at PETCO Park.

Yuki Matsui earned the win with three innings of one-hit relief, and Germán Márquez followed with five innings of one-hit ball to record the save, helping San Diego bounce back from a 4-1 loss in the series opener a night earlier. The Padres evened the four-game series at one game apiece and improved to 56-54, while the Giants fell to 47-63.

San Diego seized control quickly, scoring twice in the first inning. Fernando Tatis Jr. led off with a double, moved to third on Luis Rengifo’s single, and scored on Manny Machado’s sacrifice fly to left. Ty France walked to put two runners on, and Luis Campusano’s single to left drove in Rengifo, staking the Padres to a 2-0 lead.

The Giants managed only two hits all night, both singles, and never advanced a runner past first base. San Francisco’s only real threat came in the third inning when Christian Koss singled with two outs, but Luis Arraez struck out to end the frame. The Giants also drew a leadoff walk in the seventh, but Rafael Devers was erased on a fielder’s choice.

San Diego added to its lead in the third without the benefit of a hit. Ty France singled to start the inning, but was forced at second on Jackson Merrill’s grounder. Campusano singled to put runners at the corners, and Xander Bogaerts grounded into a double play that allowed Merrill to score, making it 3-0.

The Padres broke the game open in the fourth. Jase Bowen led off with a home run to left, his first of the season, extending the advantage to 4-0. Tatis and Rengifo walked later in the inning, and after Machado flied out, Ty France singled to center to drive in both runners, pushing the lead to 6-0.

San Francisco starter Carson Whisenhunt took the loss, falling to 2-2. The Giants went down in order in the fifth, and their only hit against the Padres’ bullpen came in the sixth when Arraez singled to center with two outs. Heliot Ramos grounded out to end the inning.

San Diego capped the scoring in the sixth. Rengifo walked, Machado doubled to center, and France delivered a sacrifice fly to center to bring home Rengifo for a 7-0 lead. The Padres stranded two runners later in the inning but had already built an insurmountable cushion.

Márquez, who had allowed four earned runs in one inning against Arizona on Aug. 4, rebounded with a sharp outing. He entered in the fourth and retired the side in order in the fifth, sixth, and seventh. Bradgley Rodriguez struck out two in a scoreless ninth inning to finish the combined three-hitter.

Ty France drove in three runs on a pair of singles and a sacrifice fly, leading San Diego’s offense. Campusano went 3 for 4 with an RBI and a run scored. Bowen added a home run and a single, while Machado had an RBI and also doubled. Tatis, who walked twice, singled and scored a run, and Rengifo reached base three times with a single and two walks.

The Padres had a chance to add more runs but grounded into two double plays, including one that still produced a run in the third. They also connected on a pair of sacrifice flies, with Machado and France each contributing one.

San Francisco’s offense, which had scored 16 runs in a blowout victory over Milwaukee earlier in the week, went quiet against San Diego pitching. The Giants struck out 10 times and managed only two hits, both off Padres pitchers. Carson Whisenhunt, the Giants’ starter, was charged with the loss but the Padres did their damage against him and the San Francisco bullpen.

The attendance was 44,057, and the game lasted 2 hours and 33 minutes.

Matsui, who improved to 2-1, worked the first three innings and allowed only one hit while striking out two. Márquez earned his first save of the season by pitching the middle five frames, scattering one hit and striking out two. Rodriguez handled the ninth.

The Giants had won their previous two games, including Thursday’s series opener in San Diego, but could not replicate that performance. San Francisco fell to 2-3 on its current road trip and lost for the seventh time in its last 10 games.

The Padres snapped a two-game losing streak and won for the fifth time in seven games. San Diego, which had lost four of its previous five head-to-head meetings with San Francisco, took back momentum in the series.

The teams will continue the series Saturday and Sunday at PETCO Park, with the Giants scheduled to play the remainder of the series before traveling to Texas to face the Rangers. San Diego will host the Giants for those two games before heading to Arizona for a four-game series.

Interstat’s game simulator had projected a final score of San Diego Padres 6, San Francisco Giants 4. Interstat’s ELO system gave the Padres a 58.00 percent probability to win. San Diego had been installed as a pregame favorite with a spread of -1.5. The total score of 7 went over the over/under line of 8.5.