MIAMI GARDENS, Fla. (Interstat) — Luis Rengifo’s pinch-hit, two-run homer in the eighth inning broke a tie and sent the San Diego Padres to a 4-2 victory over the Miami Marlins on Friday night at loanDepot Park.

The Padres won for the third time in four games, improving to 51-53, while the Marlins fell to 52-52. Attendance was 16,151 and the game lasted 3 hours, 6 minutes.

San Diego managed only five hits, but capitalized on key opportunities. Miami outhit the Padres 9-5 but stranded runners in scoring position in the seventh and eighth innings.

Miami struck first in the second inning. Catcher Joe Mack launched a 1-0 pitch over the right-field fence for his 10th home run of the season, giving the Marlins a 1-0 lead. The solo shot came off Padres starter Kyle Hart, who lasted two innings.

The Padres answered in the fourth. Manny Machado singled to left and Ty France followed with a single, putting runners at the corners with one out. Jackson Merrill then lifted a sacrifice fly to right, scoring Machado to tie the game at 1-1.

San Diego took the lead in the fifth. Xander Bogaerts walked, advanced on a sacrifice bunt by Sung-Mun Song and scored on Machado’s single to left. The ball was misplayed by left fielder Heriberto Hernández, allowing Machado to take second and Jake Cronenworth, who had walked, to reach third. But Ty France flied out to end the inning with the Padres ahead 2-1.

Miami tied it in the bottom of the fifth. Hernández led off with a line-drive home run to center, his 14th of the season, knotting the score at 2-2. The Marlins could not push across another run, as Padres reliever Germán Márquez struck out Xavier Edwards and got Liam Hicks to ground out to end the inning.

Márquez worked 2 1/3 innings, allowing three hits and one run while striking out four. He was followed by Bradgley Rodriguez, who gave up two hits in two-thirds of a scoreless inning, and Wandy Peralta, who allowed one run on two hits and struck out one in 1 2/3 innings.

The score remained 2-2 through the middle innings. Miami threatened in the seventh. Kyle Stowers singled with one out and Hernández doubled to left, putting runners at second and third. But Peralta induced a strikeout from Xavier Edwards and a groundout from Liam Hicks to escape the jam.

San Diego broke through in the eighth. Ty France led off with a double to center. After Jackson Merrill struck out, Rengifo, pinch-hitting for Luis Campusano, crushed a 2-1 pitch over the right-field fence for his second home run of the season, scoring France and giving the Padres a 4-2 lead.

Adrian Morejon earned the win, improving to 8-2. He pitched 1 1/3 scoreless innings, allowing no hits and striking out two. Mason Miller recorded his 26th save, working a 1-2-3 ninth with one strikeout.

For the Marlins, Tyler Zuber took the loss, falling to 0-1. He gave up the two-run homer in the eighth. Miami starter Lake Bachar allowed two runs on three hits over 4 1/3 innings, striking out three and walking four.

Manny Machado had two hits and an RBI for San Diego. Jackson Merrill drove in a run with a sacrifice fly. For Miami, Mack and Hernández homered, and Otto Lopez had two hits.

The Padres, who had dropped two straight at Atlanta before this win, continue their road trip with the second game of this series Saturday. The Marlins, losers of six of their last seven, will look to bounce back.

Interstat’s game simulator projected a final score of San Diego 4, Miami 1. Interstat’s ELO system gave Miami a 50.30 percent probability to win. Miami was a pregame favorite with a spread of minus-1.5. The total score of 6 went over the over/under line of 9.