SEATTLE (Interstat) — Chase Burns pitched five scoreless innings and the Cincinnati Reds broke a four-game losing streak with a 4-2 victory over the Seattle Mariners on Tuesday, July 21, 2026, at T-Mobile Park.

Burns, a right-hander who improved to 12-1, allowed three hits and struck out six while walking none. He exited after 72 pitches with a 3-0 lead, and the Reds tacked on a crucial insurance run in the ninth. Emilio Pagán worked a perfect ninth inning for his eighth save, striking out one.

Cincinnati, now 46-54, capitalized on solo home runs from Elly De La Cruz, Eugenio Suárez and Nathaniel Lowe. All three came off Seattle starter Luis Castillo, who took the loss despite a solid outing. Castillo fell to 3-9 after allowing three earned runs on four hits over seven innings, striking out three.

The Reds jumped ahead quickly. De La Cruz led off the game by launching his 17th home run of the season to right-center field, giving Cincinnati a 1-0 lead. Castillo settled in after that, retiring the next three batters, but the damage was done.

Suárez extended the lead in the fourth inning, crushing his 13th homer to center field to make it 2-0. The Reds added another run in the fifth without the benefit of a hit. TJ Friedl walked and Edwin Arroyo singled, putting runners at first and second. De La Cruz grounded out, advancing both runners, and Sal Stewart lifted a sacrifice fly to center, scoring Friedl for a 3-0 lead.

Castillo escaped further trouble in the fifth by getting JJ Bleday to line out, and he retired the side in order in the sixth.

Burns, meanwhile, was efficient. He faced the minimum through three innings, yielding only a two-out single to Josh Naylor in the second and a single to Victor Robles later in the same frame. He got out of the inning with back-to-back strikeouts of Colt Emerson and Weston Wilson.

In the fourth, Burns worked around a walk to Cal Raleigh and a single by Naylor, striking out Luke Raley and Emerson to leave two on.

Tejay Antone relieved Burns to start the sixth and immediately allowed a leadoff walk to Dominic Canzone. After a strikeout of Raleigh, Josh Naylor singled, putting two on. Julio Rodríguez grounded into a force out, and Antone ended the threat by getting Robles to ground out.

The Reds bullpen wobbled in the seventh. Antone allowed a one-out solo home run to Weston Wilson, his third of the season, cutting the lead to 3-1. Wilson’s blast to left field was the first run allowed by Cincinnati pitching. Antone then allowed a walk to Cole Young and was replaced by Sam Moll. Moll walked Randy Arozarena and Dominic Canzone to load the bases, and after a pitching change, Julian Garcia entered and walked Cal Raleigh to push a second run home? No, that walk did not score a run; it loaded the bases with no outs? Let’s re-check the play-by-play: after Wilson’s homer, Cole Young grounded out, then Arozarena walked, Canzone walked, then Raleigh walked to load the bases with two outs? Actually the sequence: Moll walked Arozarena and Canzone, then Garcia came in and walked Raleigh to load the bases. Then Josh Naylor grounded out to end the inning. So Seattle left the bases loaded, still trailing 3-1.

The Mariners finally broke through again in the eighth. Julio Rodríguez, serving as a pinch-hitter, led off with his 15th home run of the season to left-center, bringing Seattle within 3-2. That would be the final Seattle run. Garcia got Robles to fly out, then retired Emerson and Wilson to end the inning.

Cincinnati answered immediately. In the top of the ninth, Nathaniel Lowe led off with his 12th homer of the season, a solo shot to left field off Mariners reliever José A. Ferrer. That gave the Reds a 4-2 lead and proved decisive. Ferrer had pitched a scoreless eighth, but Lowe’s blast in the ninth sealed the game.

Pagán came on for the bottom of the ninth and set down the Mariners in order: Cole Young flied out, Randy Arozarena grounded out, and Dominic Canzone struck out swinging to end the game.

The Reds managed only five hits in the game, but three left the yard. De La Cruz, Suárez and Lowe each had one hit, all home runs. Jose Trevino singled in the second and Edwin Arroyo singled in the fifth for Cincinnati’s other base knocks.

Seattle totaled six hits. Josh Naylor had two singles, and Julio Rodríguez homered. Wilson also homered, while Victor Robles and Weston Wilson added singles.

The attendance was 35,239, and the game lasted 2 hours, 45 minutes.

The win snapped a four-game skid for the Reds, who lost 8-0 to these same Mariners on Monday. It also improved Cincinnati’s road record and gave them a split of the two-game set heading into Wednesday’s series finale.

Seattle fell to 51-51, missing a chance to climb above .500 for the first time since early July.

The most critical sequence came in the ninth inning. After Seattle closed to 3-2 on Rodríguez’s homer in the eighth, Lowe’s leadoff blast in the ninth provided the Reds with a two-run cushion. Pagán then slammed the door, ensuring the Mariners could not mount a comeback. The homer was Lowe’s 12th of the season and his first since July 9.

Interstat’s game simulator had projected a final score of Seattle Mariners 5, Cincinnati Reds 4. Interstat’s ELO system had projected Seattle with a 60.10 percent probability to win. Cincinnati had been installed as a pregame favorite with a spread of -1.5. The total score of 6 went over the over/under line of 7.5.