CINCINNATI (Interstat) — The Cincinnati Reds erupted for five runs in the fourth inning on three home runs and added four more in the sixth to power past the Philadelphia Phillies 11-5 on Wednesday night at Great American Ball Park.

The Phillies, who had won the series opener 4-1 a night earlier, took an early lead but could not withstand the Reds’ offensive barrage. Cincinnati’s win evened the three-game series and improved its record to 42-49, while Philadelphia fell to 51-42.

Reds starter Chase Burns earned the victory, improving to 11-1 on the season. He worked five innings, allowing three runs on five hits with four walks and four strikeouts. Phillies right-hander Alan Rangel took the loss, dropping to 0-2. Rangel lasted only three innings, surrendering two runs on two hits with two walks and four strikeouts before being lifted.

Philadelphia struck first in the second inning. Gabriel Rincones Jr. led off with a double to center field, and Justin Crawford followed with a triple to right field, scoring Rincones. Crawford later scored when Edmundo Sosa flied out to center, giving the Phillies a 2-0 lead.

Cincinnati answered in the third. Elly De La Cruz doubled to right field, and Sal Stewart followed with a home run to right field, his 18th of the season, tying the game 2-2.

The Reds then broke the game open in the fourth. Noelvi Marte led off with a solo homer to left-center, his sixth. After a flyout and a triple by Edwin Arroyo, De La Cruz crushed a two-run homer to right-center, his 14th, making it 5-2. Stewart then went back-to-back, hitting his 19th homer to right field. JJ Bleday made it three consecutive homers with a solo shot to right-center, his 14th, and the Reds led 7-2.

Philadelphia got a run back in the fifth. Bryce Harper walked, Kyle Schwarber walked, and after a flyout, Bryson Stott delivered a sacrifice fly to left field, scoring Harper to make it 7-3.

In the sixth, the Phillies cut the deficit to 7-4 on J.T. Realmuto’s solo home run to left field, his seventh. But the Reds answered emphatically in the bottom of the inning. TJ Friedl walked, De La Cruz walked, and after a flyout, Bleday singled to center, scoring Friedl. A strikeout followed, but Spencer Steer walked to load the bases. Marte then cleared the bases with a double to left field, scoring three runs and extending the lead to 11-4.

Philadelphia added a run in the ninth on Schwarber’s solo homer to right field, his 32nd, but the Reds’ lead was never threatened.

Key offensive performances for Cincinnati included Stewart, who finished 2-for-4 with two home runs and three RBIs. De La Cruz went 2-for-3 with a home run, a double and two RBIs. Marte was 2-for-5 with a home run and four RBIs. Bleday went 2-for-4 with a home run and two RBIs. Steer also contributed, going 2-for-4 with a double.

For Philadelphia, Realmuto homered, Schwarber homered, and Crawford had a triple and an RBI. Rincones doubled and scored. Harper walked three times.

The Reds used five pitchers after Burns departed. Rhett Lowder threw two innings, allowing one run on three hits with two strikeouts. Brock Burke allowed one run on two hits in one inning with two strikeouts. Caleb Ferguson pitched a scoreless inning with one strikeout.

The game lasted 3 hours, 10 minutes before a crowd of 33,089.

Philadelphia had a chance to extend its lead in the third when Brandon Marsh singled with two outs, but Bryson Stott flied out to end the inning. The Phillies also put two runners on in the fourth with walks to Justin Crawford and J.T. Realmuto, but Edmundo Sosa flied out.

Cincinnati’s defense turned two double plays, both started by third baseman Sal Stewart. In the fourth, Philadelphia’s Gabriel Rincones grounded into a 4-6-3 double play. In the seventh, Alec Bohm grounded into a 5-4-3 double play.

The Phillies challenged a play at first base in the fifth inning on a Spencer Steer ground ball, but the call was upheld. In the eighth, Philadelphia challenged a catcher interference call against Jose Trevino and won, allowing Edmundo Sosa to reach base.

Cincinnati’s offense, which had been held to one run in the series opener, exploded for 11 hits. The Phillies managed eight hits. The Reds’ four-homer fourth inning was the emphatic turning point, as they turned a 2-2 tie into a commanding five-run lead.

Philadelphia’s previous results showed a mixed bag, with the Phillies having lost five of their last six games before Wednesday. Cincinnati had dropped four of its last five before Tuesday’s loss, but the win Wednesday gave the Reds a much-needed boost.

The two teams conclude the series Thursday afternoon. Philadelphia then travels to Detroit for a weekend series against the Tigers, while Cincinnati hosts the Chicago Cubs for a three-game set beginning Friday.

Interstat’s game simulator projected a final score of Philadelphia 5, Cincinnati 4. Interstat’s ELO system gave the Phillies a 57.30 percent probability to win. Cincinnati was installed as a pregame favorite with a spread of minus-1.5. The total score of 16 went under the over-under line of 9.