CLEVELAND (Interstat) — Miguel Vargas hit a three-run home run in the fifth inning, but the Cleveland Guardians rallied to tie the game in the seventh and won 4-3 in 10 innings Friday night at Progressive Field.

The Guardians sent 33,646 home happy when Kahlil Watson singled to center field with two outs in the bottom of the 10th, scoring pinch runner Steven Kwan from third base. The hit came off Chicago White Sox reliever Sean Newcomb, who took the loss.

The win lifted Cleveland to 47-42 on the season and dropped the White Sox to 45-42. The Guardians have now won two straight against their American League Central rivals, following a 6-5 victory Thursday. The teams have split the first four meetings of 2026, with each club winning twice at home.

Chicago grabbed the lead in the top of the fifth against Guardians starter Gavin Williams. Chase Meidroth led off with a single to right field, and Tristan Peters followed with a single to left, putting runners at first and second. Jacob Gonzalez sacrificed both runners into scoring position. Sam Antonacci then hit a grounder to first baseman Rhys Hoskins, who threw home to catcher Austin Hedges to cut down Meidroth at the plate for the second out.

Vargas, batting third, then crushed a 1-0 pitch from Williams over the left-field wall for his 20th home run of the season. The three-run blast cleared the bases and gave the White Sox a 3-1 advantage. Williams struck out Kyle Teel to end the inning but had already allowed all three Chicago runs on five hits over four and two-thirds innings. He struck out six and walked two.

Cleveland had scored first in the third inning off White Sox starter Anthony Kay. Gabriel Arias led off with a walk, and Austin Hedges also walked to put two on. Kwan sacrificed the runners to second and third. Travis Bazzana then lined a single to center, scoring Arias and moving Hedges to third. David Fry grounded into a double play to end the inning, but the Guardians had cut the deficit to 1-0.

Kay pitched four innings for Chicago, allowing one earned run on one hit while striking out two. He walked three.

The White Sox held the 3-1 lead through the middle innings, but the Guardians struck in the seventh against Chicago reliever Jordan Hicks. Rhys Hoskins walked to open the inning. Kyle Manzardo struck out for the first out. Brayan Rocchio then walked, putting runners at first and second. Daniel Schneemann, pinch hitting for Arias, struck out for the second out.

Hicks then allowed a single to Hedges that scored Hoskins, cutting the lead to 3-2. Rocchio advanced to second on the play. Kwan followed with a line drive single to left field. Left fielder Sam Antonacci misplayed the ball, allowing Rocchio to score easily and Hedges to advance to third. Kwan moved to second on the error. The game was tied 3-3.

Hicks struck out Bazzana on a foul tip to end the inning. Hicks had entered in the seventh and allowed one earned run on one hit, striking out three.

Neither team scored in the eighth or ninth innings, sending the game to extra innings.

In the top of the 10th, White Sox pinch hitters Randal Grichuk and Junior Perez both struck out looking against Guardians reliever Erik Sabrowski. Antonacci then flied out to right field, ending the threat.

In the bottom of the 10th, Kwan started the inning on second base as the Manfred man. Bazzana greeted Newcomb with a single to left, moving Kwan to third. Watson then laced a single to center field, and Kwan scored easily to end the game.

Sabrowski got the victory, improving to 3-1 on the season. He pitched one perfect inning, striking out two. Newcomb fell to 0-2.

Trevor Richards pitched two scoreless innings for Chicago in the eighth and ninth, striking out three. Chris Murphy pitched a scoreless sixth with two strikeouts.

For Cleveland, Franco Aleman threw one and one-third scoreless innings, allowing no hits and striking out one. Colin Holderman pitched a scoreless eighth with a strikeout, and Cade Smith pitched a scoreless ninth.

The game lasted 2 hours, 48 minutes.

The White Sox will continue their road trip Saturday in Cleveland in the second game of the four-game series. Left-hander Garrett Crochet (6-4, 2.98 ERA) is scheduled to start for Chicago against Guardians right-hander Triston McKenzie (5-5, 4.23 ERA).

Following the series, Chicago returns home for a seven-game homestand against Boston and the Athletics. Cleveland travels to Minnesota for a three-game series before heading to Miami.

Interstat’s game simulator had projected a final score of Chicago White Sox 6, Cleveland Guardians 4. Interstat’s ELO system had projected Cleveland with a 58.40 percent probability to win. Cleveland had been installed as a pregame favorite with a spread of minus-1.5. The total score of 7 went over the over/under line of 8.5.