BOSTON (Interstat) — The Washington Nationals continued their dominance at Fenway Park, overwhelming the Boston Red Sox 10-2 on Wednesday afternoon to take the series with their second straight lopsided victory.

Andrew Alvarez earned the win in relief, improving to 2-1 on the season. Alvarez entered in the fifth inning and worked 1 1/3 scoreless innings before giving way to the bullpen. Payton Tolle took the loss for Boston, falling to 4-6 after allowing six earned runs on seven hits over three innings.

The Nationals improved to 45-43, while the Red Sox dropped to 37-48. Attendance was 32,574, and the game lasted 3 hours, 5 minutes.

Washington struck first in the opening inning. Curtis Mead tripled on a sharp line drive to right field, and Andrés Chaparro followed by crushing a home run to left-center field, giving the Nationals a 2-0 lead. Jacob Young later doubled, but the inning ended with the lead at two.

Boston threatened in the bottom of the first when Wilyer Abreu singled and Willson Contreras walked, but the Red Sox failed to push a run across. The game remained 2-0 until the fourth inning, when Washington erupted for five runs.

Nasim Nuñez led off the fourth with a solo home run to left-center field, his first of the season. Drew Millas followed with a single, and James Wood walked. After Curtis Mead also walked, Luis García Jr. delivered a two-run single to left that scored Millas and Wood. Dylan Crews singled to load the bases, and Daylen Lile grounded into a double play, but Mead scored on the play. Young then doubled to drive in García Jr., making it 7-0.

The Red Sox had a chance to rally in the fifth. Nate Eaton was hit by a pitch, and Andruw Monasterio doubled. But Eaton was thrown out at home on a fielder’s choice, and Alvarez struck out Anthony Seigler and got Ceddanne Rafaela to walk before Wilyer Abreu fanned on a foul tip, ending the threat.

Washington added three more runs in the seventh. Young walked, and after two strikeouts, Millas walked as well. Wood then launched a three-run homer to left-center field, his 22nd of the season, extending the lead to 10-0.

Boston finally got on the board in the eighth. Rafaela singled, Contreras singled, and Romy Gonzalez singled to load the bases. Caleb Durbin walked, forcing in Rafaela, and Nate Eaton grounded into a forceout that scored Contreras. But the Red Sox could not add more, leaving the bases loaded when Monasterio struck out.

The most important part of the game was Washington’s five-run fourth inning. That outburst stretched a 2-0 lead to 7-0 and effectively broke the game open. The Nationals, who had beaten Boston 8-1 the previous afternoon, seized momentum early and never let the Red Sox recover. Tolle, who had struggled with command all afternoon, could not escape the fourth, and the Boston bullpen was unable to stop the bleeding.

Key contributors for Washington included Wood, who went 1-for-2 with a walk and four RBIs, and Young, who doubled twice, walked twice and scored two runs. Nuñez also homered and walked. For Boston, Contreras had two hits, Connor Wong had two hits, and Ceddanne Rafaela had two hits, including a double. But the Red Sox stranded 10 runners and went 0-for-7 with runners in scoring position.

Alvarez pitched effectively in relief, allowing just one hit and striking out one. Boston’s Jovani Morán worked 1 2/3 scoreless innings with three strikeouts, and Alec Gamboa allowed two earned runs over 2 1/3 innings.

Interstat’s game simulator had projected a 6-4 win for Boston, and the ELO system gave the Red Sox a 60.10 percent probability to win. Boston was a pregame favorite with a spread of minus-1.5. The total of 12 runs scored went under the over/under line of 10.