PHILADELPHIA (Interstat) — Bryce Harper hit his 377th career home run and Jhoan Duran struck out the side in a perfect ninth inning to record his 13th save as the Philadelphia Phillies defeated the San Diego Padres 3-2 on Tuesday night at Citizens Bank Park.

The Phillies, who improved to 31-29, snapped a two-game losing streak and won for the fourth time in their last six games. San Diego fell to 32-27, losing for the fourth time in five contests.

Harper’s two-run blast in the fourth inning tied the score at 2-2, and Alec Bohm’s run-scoring double-play groundout in the sixth provided the decisive margin.

Philadelphia’s bullpen delivered four innings of one-hit relief after starter Aaron Nola worked five innings, allowing four hits and two earned runs while striking out eight.

San Diego took an early lead in the top of the third when Gavin Sheets hit his 10th home run of the season, a two-run shot to right field that scored Fernando Tatis Jr. after he had singled. The Padres struck first but could not sustain the momentum.

The Padres managed only one hit after the fourth inning and stranded seven runners overall.

Philadelphia answered quickly in the bottom of the fourth. Trea Turner singled to right field, and Harper followed by driving a 1-1 pitch from Padres starter Randy Vásquez over the center-field wall. The home run marked the 14th of the season for Harper and pulled the Phillies even at 2-2.

Vásquez matched Nola’s length with five innings of his own, allowing five hits and two earned runs while striking out three. He left after the fifth with the game tied.

The deciding run came in the sixth against Padres reliever Jeremiah Estrada. Harper drew a leadoff walk and Brandon Marsh singled to right field, putting runners at first and third. Bohm then grounded a ball to shortstop Xander Bogaerts, who started a double play. Harper scored on the exchange, and Marsh was erased at second base. Estrada (2-2) took the loss after allowing one run on two hits in one inning.

San Diego mounted a threat in the seventh. Xander Bogaerts walked and Jase Bowen singled, putting runners at the corners with one out. But Phillies reliever Orion Kerkering struck out Sung-Mun Song, and Brad Keller induced a forceout from Ty France to end the inning.

The Padres’ best chance to tie the game came in the eighth against Keller. Tatis singled to lead off, but Sheets flied out and Manny Machado popped out. Tatis then made a critical baserunning mistake. With two outs, Miguel Andujar hit a chopper to third baseman Bohm. Bohm faked a throw to first and instead started a rundown, and Tatis was tagged out between first and second to end the inning.

In the ninth, Duran sealed the win with three consecutive strikeouts of Jackson Merrill, Xander Bogaerts and Jase Bowen. Duran lowered his ERA to 1.80 with his 13th save in 14 opportunities.

Philadelphia’s offense scratched out nine hits but also grounded into three double plays, limiting its damage. San Diego had seven hits and also grounded into one double play.

The Phillies received strong relief work from José Alvarado, who pitched a scoreless seventh inning and earned the victory. Alvarado (2-1) struck out one and did not allow a hit.

For San Diego, Bradgley Rodriguez and Yuki Matsui each threw a scoreless inning, with Matsui striking out one.

Philadelphia’s Nola matched up against San Diego’s Vásquez in a rematch of a May 26 start in San Diego, when the Padres beat Nola 4-3. Nola allowed three hits over the first three innings and escaped a jam in the fifth after Adolis García singled and Kyle Schwarber was intentionally walked. He retired Trea Turner on a flyout to end the inning.

The Padres’ best scoring opportunity against Nola came in the third when Tatis singled and Sheets homered on a 1-0 fastball. Nola settled down and retired seven of the last eight batters he faced.

Philadelphia’s Justin Crawford had two hits, and Brandon Marsh also had two hits and a stolen base. Turner reached base twice on a single and a walk.

San Diego’s Tatis finished 3-for-4 with a double and a single, accounting for half of the Padres’ hits.

The game lasted 2 hours, 38 minutes in front of an announced crowd of 38,763.

San Diego continues its road trip Wednesday with the second game of this three-game series at Citizens Bank Park. The Padres then return home to host the New York Mets beginning Friday.

Philadelphia hosts San Diego for two more games before opening a six-game homestand against the Chicago White Sox on Friday.

The Interstat game simulator had projected a final score of Philadelphia 5, San Diego 3. Interstat’s ELO system gave Philadelphia a 54.20 percent probability to win. Philadelphia had been installed as a pregame favorite with a spread of -1.5. The total of five runs went over the over/under line of eight.