MILWAUKEE (Interstat) — The Milwaukee Brewers erupted for a seven-run second inning and never looked back, overpowering the San Francisco Giants 16-2 on Monday night at American Family Field.

A crowd of 28,154 watched the Brewers improve to 36-21, while the Giants fell to 23-37 in a matchup that was lopsided from the middle innings onward. The game lasted 2 hours, 43 minutes.

San Francisco struck first in the top of the second inning. Jung Hoo Lee led off with a single, and Matt Chapman followed by launching a two-run home run to center field, his second homer of the season, giving the Giants a 2-0 lead. But the advantage evaporated quickly.

Milwaukee answered in the bottom of the second with a barrage that chased Giants starter Landen Roupp from the game after only 1 1/3 innings. Jake Bauers drew a leadoff walk, and after Andrew Vaughn flied out, Sal Frelick doubled to drive in Bauers. Luis Rengifo singled to score Frelick, tying the game. David Hamilton laid down a bunt single, and Christian Yelich walked to load the bases. Jackson Chourio then cleared the bases with a double to left-center, scoring Rengifo and Hamilton. Brice Turang added a triple to right field, plating Yelich and Chourio, and William Contreras capped the inning with a sacrifice fly that brought home Turang. By the time the dust settled, the Brewers led 7-2.

Milwaukee tacked on a run in the fourth inning. Yelich singled, Chourio walked, and Turang walked to load the bases. Contreras grounded into a double play, but Yelich scored from third to make it 8-2.

The Brewers stretched the lead further in the sixth. Turang walked, Contreras singled, and Jake Bauers walked to load the bases. Andrew Vaughn singled to right field, scoring Turang and Contreras, and the ball was misplayed by right fielder Jung Hoo Lee, allowing Vaughn to advance to second. That gave Milwaukee a 10-2 advantage.

In the seventh, Milwaukee added two more runs. Rengifo walked, Hamilton singled, and Yelich singled to drive in Rengifo. Chourio then singled to score Hamilton, pushing the lead to 12-2.

The Brewers put the game completely out of reach with a four-run eighth inning. Rengifo singled, Hamilton doubled, and Yelich singled to bring home Rengifo. Chourio walked to load the bases, and Joey Ortiz doubled to clear them, scoring Hamilton and Yelich. Contreras added a sacrifice fly to score Chourio, making it 16-2.

Chad Patrick earned the win for Milwaukee, improving to 3-2. He held the Giants to two runs on five hits over seven innings, striking out seven and walking four. Landen Roupp took the loss, falling to 5-6. Roupp lasted only 1 1/3 innings, allowing seven runs on six hits and three walks.

San Francisco’s offense was limited to five hits. Chapman’s two-run homer was the only extra-base hit for the Giants. Eric Haase doubled, Bryce Eldridge doubled, and Luis Arraez and Jung Hoo Lee each singled. Casey Schmitt went hitless in four at-bats, and Rafael Devers, Drew Gilbert, Jonah Cox, Victor Bericoto, and Buddy Kennedy all failed to record a hit. Kennedy also pitched the eighth inning, allowing four earned runs on four hits in one inning of relief.

Milwaukee’s 18-hit attack was led by Yelich, who had three hits and two RBIs. Chourio had two hits and three RBIs, and Turang contributed a double, a triple, and two runs scored. Frelick, Rengifo, Hamilton, and Vaughn each had two hits. The Brewers drew nine walks against Giants pitching.

The most critical sequence of the game was the second inning, when San Francisco’s two-run homer was immediately answered by a seven-run outburst from Milwaukee. That inning swung the momentum decisively and set the tone for the rest of the contest.

For the Giants, the defeat was the latest in a season-long struggle. They have lost five of their last six games. Milwaukee, meanwhile, has won six of its last seven and continues to lead its division.

Interstat’s game simulator had projected a final score of Milwaukee 6, San Francisco 2. Interstat’s ELO system gave Milwaukee a 67.30 percent probability to win. Milwaukee was installed as a pregame favorite with a spread of minus-1.5. The combined total of 18 runs went under the over/under line of 7.5.