SAN DIEGO (Interstat) — Aaron Nola pitched six strong innings, Bryce Harper, Trea Turner and J.T. Realmuto each homered and the Philadelphia Phillies held off the San Diego Padres 4-3 on Tuesday night at PETCO Park.

The Phillies improved to 28-27, while the Padres fell to 31-23. Nola (3-4) allowed two runs on four hits, struck out seven and walked one. Jhoan Duran pitched a perfect ninth inning for his 11th save. Randy Vásquez (5-3) took the loss for San Diego, allowing four runs on seven hits in five innings.

Philadelphia jumped on Vásquez early. Harper led off the top of the first inning with his 13th home run of the season, a line drive to right field, giving the Phillies a 1-0 lead. The hitting stopped there for a moment, but in the second inning, Realmuto smashed his second homer of the season, a solo shot to left field, making it 2-0.

The Phillies extended their lead with two more runs in the third. Turner hit his sixth home run of the season, a fly ball to left field, making it 3-0. Harper walked, then Brandon Marsh singled sharply to center, putting runners at first and second. Alec Bohm then singled to center, driving in Harper for a 4-0 lead.

San Diego cut the deficit in half in the fourth inning. Gavin Sheets singled with one out, then Manny Machado launched his ninth home run of the season, a line drive to left field, scoring Sheets and making it 4-2.

The Padres threatened in the sixth. Xander Bogaerts reached on a soft ground ball to third base after a replay challenge overturned the original out call. But Nola escaped the inning by striking out Sheets.

In the eighth inning, San Diego pulled within one. Ramón Laureano led off with his seventh home run, a fly ball to left-center field, making it 4-3. The Padres had the tying run on base later in the inning when Fernando Tatis Jr. singled and Sheets walked, but Machado grounded out softly to third to end the threat.

Philadelphia’s bullpen held the lead. Wandy Peralta pitched a scoreless seventh inning, allowing no hits. Bradgley Rodriguez followed with 1.1 scoreless innings, striking out one. Duran closed out the game, striking out two of the three batters he faced in the ninth.

Key performances included Nola’s effective start, Duran’s save and the power display from Harper, Turner and Realmuto. For San Diego, Laureano’s home run and Machado’s two-run blast kept the game close, but the Padres managed only five hits. Jackson Merrill went 0 for 4 at the plate, and Ty France struck out three times.

The attendance was 40,399, and the game lasted 2 hours, 38 minutes.

The most important part of the game occurred in the bottom of the eighth inning when Laureano’s home run cut Philadelphia’s lead to 4-3. The Padres then put the tying run on base, but a soft groundout by Machado ended the inning, preserving the Phillies’ advantage.

Interstat’s game simulator had projected a final score of San Diego 7, Philadelphia 5, and Interstat’s ELO system had given the Padres a 53.40 percent probability to win. Philadelphia had been installed as a pregame favorite with a spread of minus-1.5. The total score of seven went over the over-under line of 7.5.