PHOENIX (Interstat) — Ketel Marte launched a three-run homer in the bottom of the ninth inning, capping a four-run rally that lifted the Arizona Diamondbacks to a 5-3 victory over the San Francisco Giants on Tuesday night at Chase Field.

Marte’s blast, his sixth of the season, erased a 3-1 deficit and sent the announced crowd of 19,548 into a frenzy after the game had been dominated by the Giants for the first eight innings. The walk-off win gave Arizona a second consecutive victory over San Francisco after a 12-2 rout Monday and improved the Diamondbacks to 24-23. The Giants dropped to 20-29.

San Francisco had built its lead on back-to-back solo home runs in the second inning from Rafael Devers and Willy Adames, part of a three-run frame that appeared to provide a comfortable cushion. But Arizona’s lineup, which had been held in check by Giants pitching through most of the game, finally broke through in the ninth.

The Diamondbacks trailed 3-1 entering the bottom of the ninth and faced Giants reliever Caleb Kilian, who entered the game with a 1-1 record and had not allowed a run in his previous two appearances. Kilian had been tasked with protecting a two-run lead after the Giants’ bullpen had retired eight consecutive Arizona hitters from the sixth through the eighth innings.

Ildemaro Vargas led off the ninth with a sharp line-drive single to right field, giving the Diamondbacks a baserunner. Lourdes Gurriel Jr. flew out to center, but Gabriel Moreno struck out swinging, putting Arizona on the brink with two outs and Vargas still on first. Adrian Del Castillo followed with a sharp line-drive single to center field, and Vargas scored to cut the deficit to 3-2.

The Giants then challenged a catcher interference call on a play in which Ryan Waldschmidt was ruled to have reached on interference by catcher Daniel Susac. The call was upheld after review, putting Waldschmidt on first and allowing pinch-runner Jose Fernandez to advance to second. That brought Marte to the plate.

Marte, who had grounded out and flown out in his previous two at-bats, worked the count and then sent a fly ball over the left-field wall, scoring Fernandez, Waldschmidt and himself to end the game. The walk-off homer was the second of Marte’s career and the fourth for the Diamondbacks this season.

The Giants had taken the lead in the second inning after a quiet first. San Francisco’s first three batters were retired in order, but the lineup erupted against Arizona starter Ryne Nelson. Devers led off the second with a solo homer to center field, his sixth of the season. Adames followed with a solo shot to left, his fifth. Matt Chapman then singled and scored on a sharp double to center by Daniel Susac, giving the Giants a 3-1 advantage.

That was all the offense San Francisco would muster. Nelson settled after the second inning, allowing only two more hits over his next 4 1/3 innings. He struck out three and walked two but did not factor into the decision. The Giants had chances to add to their lead, putting runners on base in the fifth and sixth innings, but could not push across any additional runs.

Arizona’s only run before the ninth came in the first inning. Corbin Carroll led off with a line-drive triple to center field, his sixth of the season, and scored when Giants second baseman Luis Arraez made a throwing error on the relay. That tied the game at 1, but the Diamondbacks missed opportunities to add more. Nolan Arenado doubled later in the inning but was left stranded.

The defense behind both pitching staffs was sharp. Arizona turned three double plays, including one in the fifth and another in the seventh that snuffed out potential Giants rallies. San Francisco’s Willy Adames and Luis Arraez combined for two double plays as well, but the Giants could not keep Arizona off the board in the ninth.

Arizona’s bullpen kept the game close. Kevin Ginkel pitched a perfect eighth inning, striking out three. Jonathan Loáisiga pitched the ninth and earned the victory, his first of the season against one loss. Loáisiga allowed no hits and struck out one in his inning of work.

For the Giants, Devers and Adames each recorded two hits. Devers also doubled in the fifth. Harrison Bader, Casey Schmitt and Daniel Susac each had one hit. Susac’s double in the second chased home Chapman for the Giants’ final run.

Arizona managed 10 hits despite grounding into three double plays and leaving seven runners on base. Ildemaro Vargas went 2 for 4 with two singles and a run. Adrian Del Castillo went 2 for 4 with an RBI single in the ninth. Nolan Arenado doubled twice and finished 2 for 4. Lourdes Gurriel Jr. added two singles. Gabriel Moreno went 0 for 3 but walked once.

The losing pitcher was Caleb Kilian, who allowed four runs on three hits and a walk in the ninth inning. Kilian fell to 1-2 on the season. He entered the game having thrown 21 innings with a 3.43 ERA prior to Tuesday’s outing.

The game lasted 2 hours, 38 minutes. It was the first of a two-game series at Chase Field, with the teams set to meet again Wednesday afternoon before the Giants return home to face the Chicago White Sox and the Diamondbacks host the Colorado Rockies.

Interstat’s game simulator projected a final score of Arizona 6, San Francisco 5. The Interstat ELO system gave Arizona a 54.90 percent probability to win. San Francisco had been installed as a pregame favorite with a spread of minus 1.5.