MILWAUKEE (Interstat) — The Milwaukee Brewers pounced early and never relented, defeating the San Diego Padres 7-1 on Thursday afternoon at American Family Field.

Kyle Harrison pitched five dominant innings, striking out seven and allowing five hits with no earned runs to earn his fourth win of the season against one loss. The left-hander retired the side in order in the third and fourth innings and induced weak contact throughout his 81-pitch outing. Brian Fitzpatrick followed with two innings of one-hit relief, striking out two, and Grant Anderson closed with a scoreless ninth.

The Brewers jumped on Padres starter Griffin Canning from the first pitch. Canning, who fell to 0-2, struggled with command early, issuing four walks in the opening frame. After Jackson Chourio struck out to begin the bottom of the first, Brice Turang walked, William Contreras walked and Gary Sanchez walked to load the bases. Andrew Vaughn then drew a walk to force in Turang for the game’s first run. Luis Rengifo followed with a two-run single to right field, scoring Contreras and Sanchez, and the Brewers led 3-0 after one.

Milwaukee added three more in the second inning. David Hamilton led off with a single to left, and after Chourio flied out, Turang doubled sharply to left to drive in Hamilton. Sanchez then doubled to center to score Turang, and Vaughn singled to right to plate Sanchez, extending the lead to 6-0.

The Brewers tacked on another run in the fourth. Vaughn doubled to center to lead off, and Rengifo singled up the middle to bring him home, making it 7-0. Rengifo finished 2-for-4 with three RBIs.

San Diego’s offense was stifled by Harrison and the Brewers bullpen. The Padres managed only seven hits, with Miguel Andujar doubling in the first and Nick Castellanos singling in the second, but they could not push a run across until the ninth. Harrison retired 10 of the final 12 batters he faced, striking out five of them.

The Padres threatened briefly in the fourth when Gavin Sheets singled and Ramon Laureano singled to put runners at the corners with one out, but Nick Castellanos struck out and Freddy Fermin grounded out to end the inning.

In the seventh, Castellanos doubled to left, but the Padres stranded him. San Diego finally broke through in the ninth against Brewers reliever Grant Anderson. With one out, Castellanos reached on a fielding error by first baseman Andrew Vaughn. Fermin singled to put runners at first and second, and Bryce Johnson walked to load the bases. Sung-Mun Song grounded into a forceout at second, scoring Castellanos, but Fernando Tatis Jr. grounded out to end the game.

For the Brewers, Vaughn went 2-for-3 with two RBIs. Turang had a double and an RBI, and Sanchez doubled and drove in a run. Chourio went 0-for-5, and Sal Frelick was 1-for-4.

The game took 3 hours and 1 minute in front of 34,862 fans.

The loss dropped San Diego to 25-18, while Milwaukee improved to 24-17. The two teams split the three-game series, with the Padres winning 3-1 on Wednesday and the Brewers winning 6-4 on Tuesday.

The most decisive stretch came in the first two innings, when Milwaukee sent 16 batters to the plate and scored six runs on six hits and six walks. The Brewers batted around in both the first and second innings, forcing Canning to throw 53 pitches over the first two frames. The early cushion allowed Harrison to pitch aggressively in the strike zone, and he never allowed a runner past second base after the first inning.

San Diego’s only run in the ninth was too little, too late. The Padres had been shut out for eight innings and had not advanced a runner to third base since the first inning, when Manny Machado singled and Andujar doubled to put runners at second and third with one out. Gavin Sheets grounded out to end that threat.

Milwaukee’s bullpen continued its strong work. Fitzpatrick, who entered in the sixth, retired six of the seven batters he faced, striking out two. Anderson worked a rocky ninth but escaped without further damage.

The Padres next travel to Seattle for a three-game series beginning Friday. The Brewers head to Minnesota for a three-game set.

Interstat’s game simulator projected a final score of Milwaukee 7, San Diego 5. Interstat’s ELO system gave the Brewers a 57.70 percent probability to win. Milwaukee was installed as a pregame favorite with a spread of minus-1.5.