ANAHEIM, Calif. (Interstat) — Walbert Ureña pitched six strong innings, Travis d’Arnaud hit a three-run home run and the Los Angeles Angels defeated the Chicago White Sox 8-2 on Wednesday evening at Angel Stadium of Anaheim before a crowd of 23,338.

The Angels broke the game open with a five-run second inning, erasing an early White Sox lead and never looking back. The victory improved Los Angeles to 15-23 on the season, while the White Sox fell to 17-20.

Chicago struck first in the top of the second inning. Colson Montgomery led off with a double, and Chase Meidroth followed with a single to put runners at the corners. Andrew Benintendi then lifted a sacrifice fly to center field, scoring Montgomery and giving the White Sox a 1-0 lead. After Jarred Kelenic walked and Tristan Peters struck out, Drew Romo walked to load the bases, but Sam Antonacci flied out to end the inning with the White Sox ahead by a run.

The Angels answered emphatically in the bottom of the second. Jorge Soler singled, and Jo Adell struck out before Oswald Peraza singled to put runners on first and second. Nolan Schanuel grounded into a force out, advancing Soler to third, but then d’Arnaud launched a 1-0 pitch over the left-field fence for his first home run of the season, scoring Soler and Schanuel to give the Angels a 3-1 lead. Bryce Teodosio followed with a double, and Zach Neto tripled to right field, driving in Teodosio. Mike Trout then singled on a pop-up that fell in, scoring Neto to make it 5-1. Vaughn Grissom flied out to end the inning.

The Angels added to their lead in the fourth. Teodosio singled with one out, and Neto walked. Trout flew out to left field, but Teodosio advanced to third. Grissom walked to load the bases, and Soler was hit by a pitch, forcing in Teodosio for a 6-1 lead. Jo Adell was also hit by a pitch, scoring Neto and making it 7-1. Peraza grounded out to end the inning.

The White Sox scratched across a run in the seventh. Meidroth singled, Benintendi walked, and after Randal Grichuk flied out, Derek Hill bunted into a fielder’s choice that moved Meidroth to third and Benintendi to second. Romo walked on a challenged call to load the bases, and Antonacci was hit by a pitch, scoring Meidroth to cut the deficit to 7-2. Munetaka Murakami struck out to end the inning.

Los Angeles added an insurance run in the eighth. Nolan Schanuel singled, and after Sebastian Rivero grounded out, Schanuel moved to third. Teodosio walked, and Neto hit a sacrifice fly to right field, scoring Schanuel to make it 8-2. Trout struck out to end the inning.

The White Sox mounted a brief threat in the ninth. Andrew Benintendi struck out, Randal Grichuk grounded out, but Luisangel Acuna singled. Drew Romo flied out to left to end the game.

Ureña earned his first win of the season, improving to 1-3. He allowed one earned run on two hits over six innings, striking out five and walking two. Noah Schultz took the loss for Chicago, falling to 2-2. Schultz was charged with five earned runs on five hits in two innings, with one walk and two strikeouts.

Osvaldo Bido pitched 2 1/3 scoreless innings of relief for the White Sox, allowing no hits and striking out one. Jordan Hicks worked a scoreless seventh, and Grant Taylor pitched a scoreless eighth, allowing one hit and striking out one.

For the Angels, Chase Silseth tossed two scoreless innings of relief, allowing one hit and striking out four. Drew Pomeranz struck out one in one-third of an inning, and Brent Suter allowed one earned run on one hit in two-thirds of an inning.

Offensively, d’Arnaud went 1-for-2 with the home run and three RBIs. Neto went 1-for-2 with a triple, a walk and two RBIs. Teodosio had two hits in three at-bats, including a double and a walk. Soler scored twice. Trout had one hit and one RBI.

For the White Sox, Montgomery doubled, Meidroth had two hits and scored a run. Antonacci drove in a run on the hit-by-pitch. Chicago managed only four hits in the game, all singles except for Montgomery’s double.

The Angels collected eight hits total.

The game lasted 2 hours, 34 minutes.

The White Sox had entered the series having won two of three games in San Diego and had taken the opener of this three-game set Monday with a 6-0 shutout. The Angels had lost four of their previous five games before Tuesday’s 4-3 walk-off win over Chicago.

The decisive moment of Wednesday’s contest came in the second inning when d’Arnaud’s three-run homer turned a one-run deficit into a two-run lead. The Angels added two more runs in the same inning on the Neto triple and Trout single, effectively putting the game out of reach. The White Sox never recovered, managing only two runs on four hits, and their bullpen, while effective, could not overcome the early damage.

Ureña’s outing was a bounce-back performance after he allowed four earned runs in 3 2/3 innings against Kansas City on April 25. He had also allowed one earned run in five innings against the New York Mets on May 1, but took a loss in a 4-3 game. His command Wednesday was sharp, as he worked out of a bases-loaded jam in the second inning and retired the side in order in the third.

The White Sox next play host to the Seattle Mariners starting Friday, while the Angels travel to Toronto to face the Blue Jays starting Friday.

Interstat’s game simulator had projected a final score of Chicago White Sox 6, Los Angeles Angels 2. Interstat’s ELO system had projected Los Angeles with a 51.00 percent probability to win. Chicago had been installed as a pregame favorite with a spread of minus 1.5 runs. The total of 10 runs went under the over-under line of 9 runs.