SAN FRANCISCO (Interstat) — Walker Buehler pitched into the sixth inning and the San Diego Padres erupted for five runs in the fourth inning Tuesday night, defeating the San Francisco Giants 10-5 at Oracle Park.

The Padres snapped a two-game skid and improved to 21-14, while the Giants lost their fourth straight and fell to 14-22. The attendance was 38,275 and the game lasted 2 hours, 30 minutes.

Buehler, who entered with a 1-2 record, allowed four earned runs on seven hits over 5 1/3 innings while striking out five. He benefited from a Padres offense that collected 14 hits, including three from Jackson Merrill and three from Miguel Andujar. Buehler’s counterpart, Logan Webb, took the loss after yielding seven runs—six earned—on eight hits in 4 1/3 innings. Webb fell to 2-4.

San Diego broke open a 4-4 tie with a five-run fourth inning that chased Webb. The inning began with a Gavin Sheets single, and Fernando Tatis Jr. doubled to put runners at second and third. Xander Bogaerts grounded out to drive in Sheets, and Nick Castellanos singled to score Tatis. Luis Campusano was hit by a pitch, and Sung-Mun Song doubled to center field, scoring Castellanos and Campusano. Song advanced to third on a throwing error by shortstop Willy Adames. Merrill then singled to center to bring home Song, giving San Diego a 9-4 lead.

The Padres added single runs in the second, fifth, sixth and eighth innings. Bogaerts homered to left-center in the second, his sixth of the season, to cut San Francisco’s initial lead to 4-1. In the fifth, Andujar doubled, moved to third on a Sheets single and scored on a sacrifice fly by Castellanos. In the sixth, Merrill singled, advanced to third on a Manny Machado groundout and scored on Andujar’s single to make it 10-4. In the eighth, Song singled and scored on Merrill’s double.

San Francisco struck first with two runs in the first inning. Jung Hoo Lee singled and Casey Schmitt followed with his sixth home run, a fly ball to left that scored Lee and gave the Giants a 2-0 lead. The Giants added two more in the second. Adames singled, Drew Gilbert singled and Jesus Rodriguez singled to drive in Adames. Lee then grounded into a force out, scoring Gilbert to make it 4-0.

The Giants scored their final run in the seventh when Rodriguez homered to right, his first of the season, cutting the deficit to 10-5.

Key performances included Andujar, who went 3-for-5 with a double, a triple and one RBI. Merrill finished 3-for-5 with a double, two RBIs and two runs scored. Song went 2-for-4 with a double, two RBIs and two runs. Bogaerts was 2-for-4 with a home run and two RBIs.

For the Giants, Rodriguez was 2-for-3 with a home run and two RBIs. Schmitt went 1-for-4 with a home run and two RBIs. Joel Peguero pitched a scoreless eighth inning for San Francisco, allowing one hit.

Ron Marinaccio and Jason Adam each pitched a scoreless inning of relief for San Diego, with Marinaccio striking out one.

The game featured a decisive moment in the fourth inning when the Padres sent 10 batters to the plate and turned a one-run deficit into a five-run lead. The outburst included four hits, a hit batter and a costly error.

San Diego had lost the opener of the four-game series Monday, 3-2, and had dropped four of its previous five games before Tuesday. The Padres now hold a 2-2 record against the Giants this season, with the teams meeting again Wednesday in the series finale.

San Francisco had lost three consecutive games entering Tuesday, all on the road, and had scored two runs or fewer in five of its previous six contests. The Giants’ offense showed early life but could not sustain it against Buehler and the Padres bullpen.

The Padres will send a yet-to-be-announced starter to the mound Wednesday, while the Giants will counter with a pitcher to be determined. San Diego then returns home for a four-game series against St. Louis starting Thursday. San Francisco hosts Pittsburgh for a three-game set beginning Friday.

Interstat’s game simulator had projected a final score of San Diego 4, San Francisco 2. The Interstat ELO system gave San Diego a 53.40 percent probability to win. San Francisco was installed as a pregame favorite with a spread of minus-1.5 runs. The total of 15 runs went under the over-under line of 7.5.