BOSTON (Interstat) — Brice Matthews hit a three-run homer and made a leaping catch at the center-field wall to rob Willson Contreras of a hit that spoiled a potentially big inning, leading the Houston Astros to a 6-3 victory over the Boston Red Sox on Saturday afternoon at Fenway Park.

Christian Walker added a solo homer, three hits and two RBI before leaving the game in the ninth inning after getting hit in the head by a fastball from Tyler Samaniego. Walker walked to the dugout after being hit. The Astros rebounded from a loss in the series opener Friday for just their third win in eight games.

Houston improved to 13-21, while Boston fell to 13-20.

Spencer Arrighetti earned the win, improving to 4-0, after pitching five innings and allowing one run on five hits with four strikeouts. Arrighetti, who entered with a 2.70 ERA in his previous two starts, retired 10 of the first 12 batters he faced. Connelly Early took the loss for Boston, falling to 2-2, after giving up five runs on six hits over four innings. Bryan King earned his second save with a perfect ninth inning.

The game drew 34,158 fans and lasted 2 hours, 55 minutes.

The Astros struck in the first inning. Carlos Correa walked and scored on Walker’s line-drive single to left field after Isaac Paredes also walked. But Jose Altuve grounded into a double play to end the inning with Houston leading 1-0.

Arrighetti worked around a walk and a single in the bottom of the third, helped by a double play turned by Correa and Altuve.

The top of the fourth inning proved decisive. Walker singled, then Altuve doubled to put runners at second and third. After Yainer Diaz grounded out, Matthews launched a 1-0 pitch from Early over the center-field wall for his third homer of the season, giving the Astros a 4-0 lead. Cam Smith followed with a double and scored on Correa’s single to make it 5-0.

Matthews, a rookie center fielder, also contributed defensively. In the bottom of the first, with one out and no runners on, he raced back to the wall and leaped to snare a deep fly ball by Jarren Duran, robbing a hit and preserving Arrighetti’s early momentum. The catch was among the most critical plays of the game, preventing Boston from mounting an early rally.

Boston scratched a run in the fifth. Connor Wong led off with a single, moved to third on Duran’s single and scored on Contreras’ sacrifice fly. Roman Anthony and Wilyer Abreu then walked to load the bases, but Trevor Story popped out to end the threat with the Astros still ahead 5-1.

Walker extended the lead in the top of the fifth with a solo homer to left, his eighth of the season, making it 6-1.

Boston clawed back in the seventh. After two quick outs, Contreras singled off reliever Enyel De Los Santos, and Anthony walked. Abreu singled to score Contreras, and Trevor Story’s single drove in Anthony, cutting the deficit to 6-3. Masataka Yoshida walked to load the bases, but De Los Santos struck out Ceddanne Rafaela to end the rally.

King came on for the ninth and retired Contreras, Anthony and Abreu in order on a flyout, a groundout and a groundout.

Houston pitchers combined for 16 strikes, 42 balls and 16 balls put in play. Boston pitchers combined for 12 strikes, 49 balls and 12 balls put in play. Each team grounded into two double plays.

The Astros also got strong relief from Kai-Wei Teng, who pitched 1 1/3 hitless innings with two strikeouts.

Walker’s health will be a concern for Houston moving forward. He was struck by a Samaniego fastball in the ninth inning and walked off the field under his own power. The Astros have a day game Sunday against the Red Sox before returning home to host the Los Angeles Dodgers.

Boston, which won the series opener 3-1 on Friday, continues its homestand with the series finale Sunday before traveling to Detroit for a three-game set.

Interstat’s game simulator projected a final score of Boston 4, Houston 3. Interstat’s ELO system gave Boston a 57.4 percent probability to win. The Red Sox entered as pregame favorites with a spread of minus-1.5.