MILWAUKEE (Interstat) — Nick Gonzales delivered a two-run single in the top of the 10th inning as the Pittsburgh Pirates defeated the Milwaukee Brewers 6-3 on Saturday at American Family Field, taking the series opener after a scoreless stretch from the seventh through the ninth.

Pittsburgh improved to 16-11, while Milwaukee fell to 13-13. The game, played before 40,408 fans, lasted 2 hours, 51 minutes.

Both teams scored two runs in the fourth inning and one run in the sixth, leaving the game tied 3-3 after six. Neither side dented the scoreboard in the seventh, eighth or ninth innings, setting the stage for extra innings.

The decisive frame began with Pittsburgh’s Oneil Cruz striking out swinging against Milwaukee reliever Angel Zerpa. Marcell Ozuna drew a walk, and Henry Davis — running for Ozuna as the automatic runner at second — advanced to third on a Bryan Reynolds single to left. Reynolds’ hit also moved Nick Yorke, who had entered as a pinch-runner, to second. Ryan O’Hearn grounded out to the pitcher, but Yorke advanced to third and Reynolds to second. Gonzales then lined a single to left, scoring Yorke and Reynolds to give the Pirates a 5-3 lead. Spencer Horwitz flied out to end the inning.

Yohan Ramírez, who earned the save — his first of the season — worked a 1-2-3 bottom of the 10th, striking out Jake Bauers and Tyler Black around a groundout by William Contreras. Ramírez pitched a perfect inning with two strikeouts.

Pittsburgh took an early lead in the fourth. Bryan Reynolds was hit by a pitch, and Ryan O’Hearn singled. After a forceout, Spencer Horwitz singled to center, scoring Reynolds. Jake Mangum grounded into another forceout, and Konnor Griffin singled to right, scoring Gonzales and putting the Pirates ahead 2-0. Henry Davis flied out to end the inning.

Milwaukee answered in the bottom half. Jake Bauers reached on a single and an error by left fielder Jake Mangum, moving to second. Tyler Black doubled to third, putting runners at second and third. Garrett Mitchell grounded out, scoring Bauers, and Sal Frelick’s sacrifice fly brought home Black to tie the game 2-2.

The Pirates regained the lead in the sixth. Ryan O’Hearn was hit by a pitch, and Gonzales singled. Horwitz hit a sacrifice fly to left, scoring O’Hearn, making it 3-2.

Milwaukee evened the score again in the bottom of the sixth. Bauers singled, Black singled, and after a forceout, Frelick’s sacrifice fly scored Bauers to tie it 3-3.

The game featured strong pitching performances. Milwaukee starter Jacob Misiorowski allowed three earned runs on six hits over six innings, striking out nine. Pittsburgh starter Mitch Keller gave up three earned runs on five hits over five innings, striking out six. Aaron Ashby threw two scoreless innings for the Brewers, striking out four. Abner Uribe pitched a perfect eighth with one strikeout.

For Pittsburgh, Dennis Santana worked a scoreless seventh, Isaac Mattson a scoreless eighth, and Mason Montgomery a scoreless ninth. Gregory Soto earned the win after a scoreless 10th, improving to 2-0. Zerpa took the loss, falling to 0-2.

Gonzales finished 3-for-5 with two RBIs. The Pirates totaled nine hits; the Brewers had six.

Pittsburgh had won the previous night’s game 6-0, while Milwaukee entered having lost four of its last five.

The Pirates continue their three-game series against the Brewers on Sunday before returning home to host St. Louis. Milwaukee hosts Arizona on Tuesday.

Interstat’s game simulator projected a final score of Pittsburgh 5, Milwaukee 4. Interstat’s ELO system gave Milwaukee a 63.60 percent probability to win. The Brewers were installed as a pregame favorite with a spread of minus 1.5. The total of nine runs went over the over-under line of eight.