CINCINNATI (Interstat) — The Cincinnati Reds look to secure a series win over the struggling San Francisco Giants when the teams meet Wednesday at Great American Ball Park.

First pitch is scheduled for 6:40 p.m. EDT under cloudy skies with a game-time temperature of 81 degrees.

The Reds (10-7) took the series opener 2-1 on Tuesday behind a strong start from Brady Singer. Cincinnati has won seven of its last 10 to sit near the top of the National League Central.

San Francisco (6-11) has lost four of its last five and seeks to avoid its third straight series loss. The Giants’ offense has mustered just three runs over its last three games.

The pitching matchup features right-handers seeking better consistency. The Giants will start Tyler Mahle (0-2, 6.75 ERA), who has struggled early. The Reds counter with Rhett Lowder (1-1, 4.91 ERA).

A player to watch for San Francisco is left-hander Robbie Ray, who started Tuesday’s loss. He delivered a quality start, allowing two runs over five innings with six strikeouts. Over his last four outings, Ray has a 2.25 ERA with 24 strikeouts in 22 innings.

For Cincinnati, Singer is coming off a win where he allowed one run over six innings against Miami. His season has been a mix of dominance and struggle, including a outing where he allowed five runs in 2 2/3 innings to Texas.

According to Interstat’s game simulator, the projected final score is Reds 5, Giants 3. Despite the simulation and Cincinnati’s better record, San Francisco has been installed as a pregame favorite with a spread of -1.5. The over/under is set at 8.5 runs.

Following Wednesday’s game, the clubs conclude their four-game series Thursday before both embark on road trips. The Giants travel to Washington for three games, while the Reds head to Minnesota for a three-game set starting Friday.