CINCINNATI (Interstat) — The Boston Red Sox and Cincinnati Reds will look to shake off season-ending losses from last fall when they open their 2026 campaigns against each other Thursday afternoon at Great American Ball Park.

First pitch is scheduled for 6:40 p.m. EDT under cloudy skies with a game-time temperature near 69 degrees.

The Red Sox, who went 0-0 in the preseason, were shut out 4-0 by the New York Yankees in their final game of the 2025 season on Oct. 2. The Reds, also 0-0, concluded their 2025 schedule with an 8-4 loss to the Los Angeles Dodgers on Oct. 1.

Boston will hand the ball to left-hander Garrett Crochet. Cincinnati counters with left-hander Andrew Abbott. Both pitchers’ season records are 0-0.

According to Interstat’s game simulator, the series opener projects to be a tight, low-scoring affair with a predicted final of Boston 2, Cincinnati 1.

This game marks the start of a three-game weekend series between the clubs. Following Thursday’s contest, the teams will meet again Saturday and Sunday in Cincinnati before both embark on extended road trips.

The Red Sox will continue their season-opening journey with a three-game set against the Houston Astros beginning Monday. The Reds will remain at home to host the Pittsburgh Pirates for three games starting Monday.

Thursday’s opener offers both teams a fresh start and an early opportunity to build momentum in the American League and National League races, respectively.