| # | Date | Time | Opponent | Top Performer | Record | Score |
|---|---|---|---|---|---|---|
| 1 | 2020-09-05 | @ Crawley Town | Scott Malone 90min 1g | 1-0 | 3-1 W | |
| 2 | 2020-09-15 | vs Cheltenham Town | Ryan Leonard 90min 1g | 2-0 | 3-1 W | |
| 3 | 2020-09-23 | vs Burnley | Bartosz Bialkowski 90min | 2-1 | 0-2 L | |
| 4 | 2020-10-29 | @ Preston North End FC | Jed Wallace 90min 1g | 3-1 | 2-0 W | |
| 5 | 2020-10-31 | 10:00 PM ET | vs Huddersfield Town | Bartosz Bialkowski 90min | 3-2 | 0-3 L |
| 6 | 2020-11-04 | @ Norwich City | Bartosz Bialkowski 90min | 3-2 | 0-0 D | |
| 7 | 2020-11-07 | 10:00 PM ET | @ Sheffield Wed | Bartosz Bialkowski 90min | 3-2 | 0-0 D |
| 8 | 2020-11-21 | 10:00 PM ET | vs Cardiff City | Matt Smith 76min 1g | 3-2 | 1-1 D |
| 9 | 2020-11-26 | vs Reading | Jed Wallace 90min 1g | 3-2 | 1-1 D | |
| 10 | 2020-11-28 | 10:00 PM ET | @ Birmingham City FC | Bartosz Bialkowski 90min | 3-2 | 0-0 D |
| 11 | 2020-12-03 | @ Blackburn Rovers FC | Scott Malone 90min 1g | 3-3 | 1-2 L | |
| 12 | 2020-12-05 | 10:00 PM ET | vs Derby County FC | Bartosz Bialkowski 90min | 3-4 | 0-1 L |
| 13 | 2020-12-09 | vs QPR | Bartosz Bialkowski 90min | 3-4 | 1-1 D | |
| 14 | 2020-12-12 | 10:00 PM ET | @ Middlesbrough | Bartosz Bialkowski 90min | 3-5 | 0-3 L |
| 15 | 2020-12-16 | @ Bristol City FC | Tom Bradshaw 81min 1g | 4-5 | 2-0 W | |
| 16 | 2020-12-19 | 10:00 PM ET | vs Nottingham Forest | Tom Bradshaw 72min 1g | 4-5 | 1-1 D |
| 17 | 2021-01-02 | 10:00 PM ET | vs Coventry City FC | Jake Cooper 90min 1g | 4-6 | 1-2 L |
| 18 | 2021-01-09 | @ Boreham Wood | Shaun Hutchinson 90min 1g | 5-6 | 2-0 W | |
| 19 | 2021-01-13 | @ Bournemouth | Bartosz Bialkowski 90min | 5-6 | 1-1 D | |
| 20 | 2021-01-16 | 10:00 PM ET | @ Nottingham Forest | Bartosz Bialkowski 90min | 5-7 | 1-3 L |
| 21 | 2021-01-21 | @ Huddersfield Town | Scott Malone 90min 1g | 6-7 | 1-0 W | |
| 22 | 2021-01-23 | vs Bristol City FC | Frank Fielding 90min | 6-8 | 0-3 L | |
| 23 | 2021-01-27 | vs Watford FC | Bartosz Bialkowski 90min | 6-8 | 0-0 D | |
| 24 | 2021-01-30 | 10:00 PM ET | @ Cardiff City | Bartosz Bialkowski 90min | 6-8 | 1-1 D |
| 25 | 2021-02-03 | vs Norwich City | Bartosz Bialkowski 90min | 6-8 | 0-0 D | |
| 26 | 2021-02-06 | 10:00 PM ET | vs Sheffield Wed | Scott Malone 90min 1g | 7-8 | 4-1 W |
| 27 | 2021-02-13 | 10:00 PM ET | @ Reading | Bartosz Bialkowski 90min | 8-8 | 2-1 W |
| 28 | 2021-02-18 | vs Birmingham City FC | Jed Wallace 87min 1g | 9-8 | 2-0 W | |
| 29 | 2021-02-20 | 10:00 PM ET | vs Wycombe | Bartosz Bialkowski 90min | 9-8 | 0-0 D |
| 30 | 2021-02-24 | @ Luton Town | George Evans 90min 1g | 9-8 | 1-1 D | |
| 31 | 2021-02-27 | 11:00 AM ET | @ Barnsley | Mason Bennett 85min 1g | 9-9 | 1-2 L |
| 32 | 2021-03-02 | 3:00 PM ET | vs Preston North End FC | Scott Malone 90min 1g | 10-9 | 2-1 W |
| 33 | 2021-03-06 | 11:00 AM ET | vs Blackburn Rovers FC | Bartosz Bialkowski 90min | 10-10 | 0-2 L |
| 34 | 2021-03-13 | 11:00 AM ET | @ Derby County FC | Shaun Hutchinson 90min 1g | 11-10 | 1-0 W |
| 35 | 2021-03-17 | 3:00 PM ET | @ QPR | Jed Wallace 90min 1g | 11-11 | 2-3 L |
| 36 | 2021-03-20 | 11:00 AM ET | vs Middlesbrough | Bartosz Bialkowski 90min | 12-11 | 1-0 W |
| 37 | 2021-04-02 | 10:00 AM ET | vs Rotherham United | Jed Wallace 73min 1g | 13-11 | 1-0 W |
| 38 | 2021-04-05 | 10:00 AM ET | @ Stoke City FC | Mason Bennett 82min 1g | 14-11 | 2-1 W |
| 39 | 2021-04-10 | vs Swansea City | Bartosz Bialkowski 90min | 14-12 | 0-3 L | |
| 40 | 2021-04-17 | @ Brentford U18 | Bartosz Bialkowski 90min | 14-12 | 0-0 D | |
| 41 | 2021-04-21 | vs Bournemouth | Jed Wallace 78min 1g | 14-13 | 1-4 L | |
| 42 | 2021-04-24 | @ Watford FC | Bartosz Bialkowski 90min | 14-14 | 0-1 L | |
| 43 | 2021-05-01 | vs Bristol City FC | Scott Malone 90min 1g | 15-14 | 4-1 W | |
| 44 | 2021-05-08 | @ Coventry City FC | Bartosz Bialkowski 90min | 15-15 | 1-6 L | |
| 45 | 2021-07-10 | TBA | @ Motherwell | 16-15 | 2-0 W | |
| 46 | 2021-07-27 | TBA | @ Gillingham | 16-15 | 1-1 D | |
| 47 | 2021-07-31 | TBA | @ Ipswich Town FC | 17-15 | 3-0 W |