| # | Date | Time | Opponent | Top Performer | Record | Score |
|---|---|---|---|---|---|---|
| 1 | 2026-08-21 | 6:00 PM ET | vs AC Monza | Francesco Esposito 90min 1g 1a | 1-0 | 4-1 W |
| 2 | 2026-08-29 | 6:00 PM ET | @ Cagliari | Nicolò Barella 90min 1a | 2-0 | 1-0 W |
| 3 | 2026-09-04 | 6:00 PM ET | vs Napoli | Josep Martinez 90min | 3-0 | 3-2 W |
| 4 | 2026-09-05 | 6:00 PM ET | vs Napoli | 4-0 | 0-0 W | |
| 5 | 2026-09-13 | 6:00 PM ET | vs Udinese | Nicolò Barella 90min 1g | 5-0 | 5-3 W |
| 6 | 2026-09-18 | 6:00 PM ET | @ AS Roma | Josep Martinez 90min | 5-0 | 2-2 D |
| 7 | 2026-10-03 | vs Lumezzane | 6-0 | 2-0 W | ||
| 8 | 2026-10-10 | 6:00 PM ET | vs Parma | Petar Sucic 90min 1g | 7-0 | 3-0 W |
| 9 | 2026-10-13 | 3:00 PM ET | vs Club Brugge KV | Lautaro Martinez 90min 2g | 7-1 | 3-4 L |
| 10 | 2026-10-16 | 6:00 PM ET | @ Bologna | |||
| 11 | 2026-10-17 | 6:00 PM ET | @ Bologna | |||
| 12 | 2026-10-24 | 6:00 PM ET | vs Fiorentina | |||
| 13 | 2026-10-27 | 6:00 PM ET | @ Venezia | |||
| 14 | 2026-10-31 | 6:00 PM ET | @ AC Milan | |||
| 15 | 2026-11-07 | 6:00 PM ET | vs Como | |||
| 16 | 2026-11-21 | 6:00 PM ET | @ Atalanta | |||
| 17 | 2026-11-28 | 6:00 PM ET | vs Genoa | |||
| 18 | 2026-12-01 | 3:00 PM ET | vs Genoa | |||
| 19 | 2026-12-01 | 6:00 PM ET | vs Genoa | |||
| 20 | 2026-12-05 | 6:00 PM ET | @ Frosinone | |||
| 21 | 2026-12-12 | 6:00 PM ET | vs Torino | |||
| 22 | 2026-12-19 | 6:00 PM ET | @ Lecce | |||
| 23 | 2027-01-02 | 6:00 PM ET | vs Sassuolo | |||
| 24 | 2027-01-05 | 6:00 PM ET | @ Lazio | |||
| 25 | 2027-01-09 | 6:00 PM ET | vs Juventus | |||
| 26 | 2027-01-16 | 6:00 PM ET | @ Parma | |||
| 27 | 2027-01-23 | 6:00 PM ET | vs Venezia | |||
| 28 | 2027-01-30 | 6:00 PM ET | @ Napoli | |||
| 29 | 2027-02-06 | 6:00 PM ET | vs Cagliari | |||
| 30 | 2027-02-13 | 6:00 PM ET | vs AC Milan | |||
| 31 | 2027-02-20 | 6:00 PM ET | @ Fiorentina | |||
| 32 | 2027-02-27 | 6:00 PM ET | vs Atalanta | |||
| 33 | 2027-03-06 | 6:00 PM ET | @ Udinese | |||
| 34 | 2027-03-13 | 6:00 PM ET | @ Torino | |||
| 35 | 2027-03-20 | 6:00 PM ET | vs Frosinone | |||
| 36 | 2027-04-03 | 6:00 PM ET | @ Genoa | |||
| 37 | 2027-04-10 | 6:00 PM ET | vs AS Roma | |||
| 38 | 2027-04-17 | 6:00 PM ET | @ AC Monza | |||
| 39 | 2027-04-24 | 6:00 PM ET | vs Bologna | |||
| 40 | 2027-05-01 | 6:00 PM ET | @ Como | |||
| 41 | 2027-05-08 | 6:00 PM ET | vs Lecce | |||
| 42 | 2027-05-15 | 6:00 PM ET | @ Juventus | |||
| 43 | 2027-05-22 | 6:00 PM ET | vs Lazio | |||
| 44 | 2027-05-29 | 6:00 PM ET | @ Sassuolo |