MEXICO CITY (Interstat) — Two Liga MX sides seeking momentum will meet Wednesday when Atlético San Luis hosts Santos Laguna.

The match at Estadio Alfonso Lastras comes after both teams suffered lopsided defeats in their previous outings. San Luis (3-5-2) is looking to rebound from a 5-2 road loss to Querétaro on Sunday. Santos Laguna (2-4-4) fell 1-0 at home to Atlas on the same day, its second straight defeat.

Recent history heavily favors the visitors. In the last head-to-head meeting on Sept. 21, 2025, Santos Laguna routed San Luis 4-1 on the road. San Luis has not beaten Santos Laguna in league play since 2021.

Form, however, has been inconsistent for both clubs. Santos Laguna’s defense has been a particular concern, conceding four goals in each of its last two road games — a 4-2 loss at Atlas and a 4-2 defeat at Pachuca earlier this month. Its last win came on March 22.

San Luis has shown flashes, including a 2-1 road win over Monterrey this month, but followed it with a 2-0 home loss to Pumas UNAM. Its defensive record at home is mixed, with two clean sheets but also two multi-goal concessions in its last five home fixtures.

The Interstat game simulator projects a 1-1 draw.

Santos Laguna will aim for its prolific attack, led by striker Juan Brunetta, to exploit a San Luis backline that has allowed eight goals in its last three matches across all competitions. San Luis will rely on home support and the creative play of midfielder Vitinho to spark its offense.

After this match, San Luis faces a quick turnaround with an international friendly at FC JJK Jyvaskyla in Finland on Saturday. Santos Laguna remains in Liga MX play, hosting Monterrey next Sunday.

Kickoff is set for 9 p.m. local time (10 p.m. EDT).