- 2024-09-14 2y Manchester Utd 3 at Southampton 0 Matthijs de Ligt ENG-MANH 87min 1g
- 2023-03-12 3y Southampton 0 at Manchester Utd 0
- 2022-08-27 4y Manchester Utd 1 at Southampton 0 Bruno Miguel Borges Fernandes ENG-MANC 90min 1g
- 2022-02-12 4y Southampton 1 at Manchester Utd 1
- 2021-08-22 5y Manchester Utd 1 at Southampton 1
- 2021-02-02 5y Southampton 0 at Manchester Utd 9 Bruno Miguel Borges Fernandes ENG-MANC 90min 1g
- 2020-11-29 5y Manchester Utd 3 at Southampton 2 Edinson Roberto Cavani Gómez ENG-MANC 44min 2g
- 2020-07-13 6y Southampton 2 at Manchester Utd 2
- 2019-03-02 7y Southampton 2 at Manchester Utd 3 Andreas Hugo Hoelgebaum Pereira ENG-MANC 82min 1g
- 2018-12-01 7y Manchester Utd 2 at Southampton 2
- 2017-12-30 8y Southampton 0 at Manchester Utd 0
- 2017-09-23 9y Manchester Utd 1 at Southampton 0 Romelu Lukaku Menama ENG-MANC 90min 1g yc
- 2017-05-17 9y Manchester Utd 0 at Southampton 0
- 2017-02-26 9y Southampton 2 at Manchester Utd 3 Zlatan Ibrahimović ENG-MANC 90min 2g
- 2016-08-19 10y Southampton 0 at Manchester Utd 2 Zlatan Ibrahimović ENG-MANC 90min 2g
- 2016-01-23 10y Southampton 1 at Manchester Utd 0 Charlie Austin ENG-SOUZ 11min 1g
- 2015-09-20 11y Manchester Utd 3 at Southampton 2 Anthony Martial ENG-MANC 90min 2g
- 2015-01-11 11y Southampton 1 at Manchester Utd 0 Dušan Tadić ENG-SOUZ 27min 1g
- 2014-12-08 11y Manchester Utd 2 at Southampton 1 Robin van Persie ENG-MANC 90min 2g
- 2014-05-11 12y Manchester Utd 1 at Southampton 1
- 2013-10-19 13y Southampton 1 at Manchester Utd 1
- 2013-01-30 13y Southampton 1 at Manchester Utd 2 Wayne Mark Rooney ENG-MANC 90min 2g
- 2012-09-02 14y Manchester Utd 3 at Southampton 2 Robin van Persie ENG-MANC 90min 3g
- 2011-01-30 15y Manchester Utd 2 at Southampton 1 Michael Owen ENG-MANC 90min 1g
- 2009-01-04 17y Manchester Utd 3 at Southampton 0 Luís Carlos Almeida da Cunha ENG-MANC 90min 1g
- 2005-05-15 21y Manchester Utd 2 at Southampton 1 Darren Fletcher ENG-MANC 90min 1g
- 2005-03-12 21y Manchester Utd 4 at Southampton 0
- 2004-12-04 21y Southampton 0 at Manchester Utd 3 Paul Scholes ENG-MANC 90min 1g
- 2004-01-31 22y Southampton 2 at Manchester Utd 3 Paul Scholes ENG-MANC 90min 1g
- 2003-08-31 23y Manchester Utd 0 at Southampton 1 James Beattie ENG-SOUZ 90min 1g
- 2003-01-31 23y Manchester Utd 2 at Southampton 0
- 2002-11-01 23y Southampton 1 at Manchester Utd 2
- 2002-01-12 24y Manchester Utd 3 at Southampton 1
- 2001-12-21 24y Southampton 1 at Manchester Utd 6
- 2000-10-27 25y Southampton 0 at Manchester Utd 5
- 2000-04-21 26y Manchester Utd 3 at Southampton 1
- 1999-02-26 27y Southampton 1 at Manchester Utd 2
- 1998-10-02 28y Manchester Utd 3 at Southampton 0
- 1998-01-18 28y Manchester Utd 0 at Southampton 1
- 1997-08-12 29y Southampton 0 at Manchester Utd 1
- 1997-01-31 29y Southampton 1 at Manchester Utd 2
- 1996-10-25 29y Manchester Utd 3 at Southampton 6
- 1996-04-12 30y Manchester Utd 1 at Southampton 3
- 1995-11-17 30y Southampton 1 at Manchester Utd 4
- 1995-05-09 31y Southampton 1 at Manchester Utd 2
- 1994-12-30 31y Manchester Utd 2 at Southampton 2
- 1994-05-03 32y Southampton 0 at Manchester Utd 2
- 1993-02-19 33y Southampton 1 at Manchester Utd 2
- 1992-08-23 34y Manchester Utd 1 at Southampton 0
- 1992-04-15 34y Southampton 0 at Manchester Utd 1