PITTSBURGH (Interstat) — Syracuse will open its road schedule Thursday, Sept. 17, 2026, against Pittsburgh in a Football Bowl Subdivision game at Acrisure Stadium. The Orange enter 1-0, while the Panthers are 0-0. The forecast at game time calls for rain and a temperature of 76 degrees.

Syracuse opened the season Sept. 5 with a 66-3 home win over New Hampshire. Quarterback Steve Angeli, a player to watch, completed 20 of 29 passes for 263 yards and three touchdowns. Amari Odom added a 2-yard touchdown run and completed 2 of 3 passes for 12 yards. Malachi Nelson attempted two passes without a completion.

Pittsburgh last played Dec. 27, 2025, losing 23-17 at East Carolina. The Panthers’ most recent listed result this season was a 0-0 outcome against Miami (Ohio) on Sept. 5, 2026. Pittsburgh will seek its first win of the season in its home opener.

The Orange will look to build on a productive opening performance behind Angeli and a passing game that produced three touchdowns. Syracuse’s defense will face a Pittsburgh team playing its first game of the 2026 season. The Panthers will try to establish their offense at home after a long layoff.

Syracuse’s upcoming schedule includes road games at Connecticut on Oct. 3 and at Virginia on Oct. 10. The Orange will host Louisville on Oct. 17, then visit North Carolina on Oct. 24. Syracuse will host SMU on Oct. 31, Clemson on Nov. 7, and Notre Dame on Nov. 28. Road games at North Carolina State on Nov. 14 and Boston College on Nov. 21 are also ahead.

Pittsburgh will host Bucknell on Sept. 26 before visiting Virginia Tech on Friday, Oct. 2. The Panthers will host North Carolina on Oct. 10 and then visit Boston College on Oct. 17 and Miami (FL) on Oct. 24. Pittsburgh will host Georgia Tech on Oct. 31 and Florida State on Friday, Nov. 13. The Panthers will visit Louisville on Nov. 21 and California on Nov. 28.

The game will be played at Acrisure Stadium in Pittsburgh, Pa. Syracuse carries a 1-0 record into the contest, while Pittsburgh is 0-0. The Orange and Panthers will meet in an early-season nonconference matchup. Weather conditions could affect both teams, with rain in the forecast.

Interstat’s game simulator projects a final score of Pittsburgh 29, Syracuse 24. Interstat’s ELO system gives Pittsburgh an 88.6 percent probability to win. Syracuse has been installed as a pregame favorite with a spread of +10.5. The over/under is 51.5.